111712-08-4Relevant articles and documents
Cesium salts as superior catalysts for solvent-free modifications of biosourced pterolactam
Dascalu, Anca-Elena,Ghinet, Alina,Lipka, Emmanuelle,Collinet, Marion,Rigo, Benoit,Billamboz, Muriel
, p. 32 - 39 (2019)
γ-Lactam derivatives are widespread biologically active compounds, covering a large range of activities. Following our interest in both medicinal and green chemistries, we developed an original, cesium salts-mediated, scalable and solvent-free methodology to transform biosourced pyroglutamic acid and its derivatives to their N,N′-aminals, N,O,N,S-acetals and C5-substituted γ-lactams in good to excellent yields. This protocol is applicable to a large range of substrates, conducting to C5-substituted γ-lactam derivatives as potential new biologically active compounds.