111727-06-1Relevant articles and documents
ARYL TRIFLUOROMETHYL ACETYLENES
Bunch, J. E.,Bumgardner, C. L.
, p. 313 - 318 (1987)
A wide variety of aryl trifluoromethyl acetylenes may be prepared in high yield by allowing CF3CCZnCl, generated from CF3CCH, to react with aryl iodides and a catalytic amount of tetrakis(triphenylphosphine)palladium
Copper-catalyzed oxidative trifluoromethylation of terminal alkynes and aryl boronic acids using (trifluoromethyl)trimethylsilane
Jiang, Xueliang,Chu, Lingling,Qing, Feng-Ling
experimental part, p. 1251 - 1257 (2012/03/22)
Trifluoromethylated acetylenes and arenes are widely applicable in the synthesis of pharmaceuticals and agrochemicals. In 2010, our group has reported the copper-mediated oxidative trifluomethylation of terminal alkynes and aryl boronic acids. This method allows a wide range of functional group tolerant trifluoromethylated acetylenes and arenes to be easily prepared. After the preliminary mechanistic studies of the oxidative trifluoromethylation of terminal alkyne, an efficient copper-catalyzed oxidative trifluoromethylation of terminal alkynes and aryl boronic acids has been developed. The catalytic protocol is successfully achieved by adding both the substrate and a portion of CF3TMS slowly using a syringe pump to the reaction mixture.
Preparation of 1-Aryl- or 1-Alkenyl-2-(perfluoroalkyl)acetylenes
Yoneda, Norihiko,Matsuoka, Shigeru,Miyaura, Norio,Fukuhara, Tsuyoshi,Suzuki, Akira
, p. 2124 - 2126 (2007/10/02)
1-Aryl- or 1-alkenyl-2-(perfluoroalkyl)acetylenes were produced in high yields by coupling reaction of aryl or alkenyl iodides with (perfluoroalkynyl)zinc compounds prepared from the corresponding (perfluoroalkyl)acetylenes in the presence of Pd catalyst.
