111760-50-0

Basic information

• Product Name: 2,4-dichloro-5-fluorobenzoylacetic acid
• Synonyms: 2,4-dichloro-5-fluorobenzoylacetic acid
• CAS NO: 111760-50-0
• Molecular Weight: 251.041
• Mol File: 111760-50-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,4-dichloro-5-fluorobenzoylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dichloro-5-fluorobenzoylacetic acid(111760-50-0)
• EPA Substance Registry System: 2,4-dichloro-5-fluorobenzoylacetic acid(111760-50-0)

Safety Data

• Hazardous Substances Data: 111760-50-0(Hazardous Substances Data)

Upstream product

• 704-10-9 2,4-dichloro-5-fluoroacetophenone 

Downstream Products

• 103319-17-1 methyl 2,4-dichloro-5-fluoro-benzoylacetate 
• 129527-63-5 7-(3-ethylaminomethyl-1-pyrrolidinyl)-6-fluoro-1-(4-fluoro-2-methylphenyl)-1,4-dihydro-4-oxocinnoline-3-carboxylic acid 
• 114610-11-6 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxocinnoline-3-carboxylic acid 
• 129527-61-3 6-fluoro-1-(4-fluoro-2-methylphenyl)1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxocinnoline-3-carboxylic acid 
• 129527-59-9 6-fluoro-1-(4-fluoro-2-methylphenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)cinnoline-3-carboxylic acid 
• 114610-10-5 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-cinnoline-3-carboxylic acid 
• 129527-47-5 methyl-2,4-dichloro-5-fluoro-α-(4-fluoro-2-methylphenylhydrazono)benzoylacetate 
• 129554-49-0 methyl 7-chloro-6-fluoro-1-(4-fluoro-2-methylphenyl)-1,4-dihydro-4-oxocinnoline-3-carboxylate 
• 129527-48-6 methyl 7-chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxocinnoline-3-carboxylate 
• 129527-44-2 methyl 2,4-dichloro-5-fluoro-α-(4-fluorophenylhydrazono)benzoylacetate 
• 114610-09-2 7-chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxocinnoline-3-carboxylic acid 
• 129527-52-2 7-chloro-6-fluoro-1-(4-fluoro-2-methylphenyl)-1,4-dihydro-4-oxocinnoline-3-carboxylic acid 

Relevant articles and documents

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME 1-ARYL-1,4-DIHYDRO-4-OXOCINNOLINE-3-CARBOXYLIC ACIDS

The coupling reaction of corresponding benzene diazonium chlorides with benzoyl acetates IIIa-IIIc yielded intermediates IVa-IVe.Their intermolecular nucleophilic cyclization provided 1-aryl-1,4-dihydro-4-oxocinnoline-3-carboxylates Va-Ve.Compounds Va, Vb, Vd, and Ve were hydrolyzed to acids VIa-VIc.Treatment of these acids with the respective cyclic amines yielded compounds VIIa-VIIg which were converted to their hydrochlorides.All compounds prepared were tested for their antimicrobial activity in vitro.