111823-25-7

Basic information

• Product Name: (S)-2-(4-{[2-Amino-5-(7-ethoxycarbonyl-heptylcarbamoyl)-4-oxo-3,4,5,6,7,8-hexahydro-pteridin-6-ylmethyl]-amino}-benzoylamino)-pentanedioic acid
• CAS NO: 111823-25-7
• Molecular Weight: 658.712
• Mol File: 111823-25-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-(4-{[2-Amino-5-(7-ethoxycarbonyl-heptylcarbamoyl)-4-oxo-3,4,5,6,7,8-hexahydro-pteridin-6-ylmethyl]-amino}-benzoylamino)-pentanedioic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(4-{[2-Amino-5-(7-ethoxycarbonyl-heptylcarbamoyl)-4-oxo-3,4,5,6,7,8-hexahydro-pteridin-6-ylmethyl]-amino}-benzoylamino)-pentanedioic acid(111823-25-7)
• EPA Substance Registry System: (S)-2-(4-{[2-Amino-5-(7-ethoxycarbonyl-heptylcarbamoyl)-4-oxo-3,4,5,6,7,8-hexahydro-pteridin-6-ylmethyl]-amino}-benzoylamino)-pentanedioic acid(111823-25-7)

Safety Data

• Hazardous Substances Data: 111823-25-7(Hazardous Substances Data)

Upstream product

• 29833-31-6 8-aminooctanoic acid ethyl ester hydrochloride 
• 1002-57-9 8-Aminooctanoic acid 
• 135-16-0 tetrahydrofolic acid 
• 78241-55-1 ethyl 6-isocyanatocaprylate 

Relevant articles and documents

Potential anticancer agents: 5-(N-substituted-aminocarbonyl)- and 5-(N-substituted-aminothiocarbonyl)-5,6,7,8-tetrahydrofolic acids

5-[[N-[(Ethoxycarbonyl)alkyl]amino]carbonyl] (6-9) and the corresponding aminothiocarbonyl (12-15) derivatives of 5,6,7,8-tetrahydrofolic acid were prepared as multisubstrate analogues of the substrate-cofactor adduct in the reactions catalyzed by the folate-mediated one-carbon transfer reactions. Evaluation in vitro showed that 7 (alkyl = hexyl) was cytotoxic to H.Ep-2 cells (ED50, 4 μM) but noncytotoxic to proliferating L1210 cells. No activity was observed for 7 against the P388 leukemia in mice.