111823-26-8

Basic information

• Product Name: L-Glutamic acid, N-[4-[[[2-amino-5-[[(6-ethoxy-6-oxohexyl)amino]thioxomethyl]-1,4,5,6,7, 8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-
• CAS NO: 111823-26-8
• Molecular Formula: C28H38N8O8S
• Molecular Weight: 646.725
• Mol File: 111823-26-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Glutamic acid, N-[4-[[[2-amino-5-[[(6-ethoxy-6-oxohexyl)amino]thioxomethyl]-1,4,5,6,7, 8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Glutamic acid, N-[4-[[[2-amino-5-[[(6-ethoxy-6-oxohexyl)amino]thioxomethyl]-1,4,5,6,7, 8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-(111823-26-8)
• EPA Substance Registry System: L-Glutamic acid, N-[4-[[[2-amino-5-[[(6-ethoxy-6-oxohexyl)amino]thioxomethyl]-1,4,5,6,7, 8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-(111823-26-8)

Safety Data

• Hazardous Substances Data: 111823-26-8(Hazardous Substances Data)

Upstream product

• 60-32-2 6-aminohexanoic acid 
• 3633-17-8 ethyl 6-aminocaproate hydrochloride 
• 135-16-0 tetrahydrofolic acid 
• 16424-03-6 ethyl 6-isothiocyanatohexanoate 

Relevant articles and documents

Potential anticancer agents: 5-(N-substituted-aminocarbonyl)- and 5-(N-substituted-aminothiocarbonyl)-5,6,7,8-tetrahydrofolic acids

5-[[N-[(Ethoxycarbonyl)alkyl]amino]carbonyl] (6-9) and the corresponding aminothiocarbonyl (12-15) derivatives of 5,6,7,8-tetrahydrofolic acid were prepared as multisubstrate analogues of the substrate-cofactor adduct in the reactions catalyzed by the folate-mediated one-carbon transfer reactions. Evaluation in vitro showed that 7 (alkyl = hexyl) was cytotoxic to H.Ep-2 cells (ED50, 4 μM) but noncytotoxic to proliferating L1210 cells. No activity was observed for 7 against the P388 leukemia in mice.