1119825-34-1Relevant articles and documents
Carbamoylcholine analogs as nicotinic acetylcholine receptor agonists-Structural modifications of 3-(dimethylamino)butyl dimethylcarbamate (DMABC)
Hansen, Camilla P.,Jensen, Anders A.,Balle, Thomas,Bitsch-Jensen, Klaus,Hassan, Mohamud M.,Liljefors, Tommy,Frolund, Bente
supporting information; experimental part, p. 87 - 91 (2009/09/25)
Compounds based on the 3-(dimethylamino)butyl dimethylcarbamate (DMABC) scaffold were synthesized and pharmacologically characterized at the α4β2, α3β4, α4β4 and α7 neuronal nicotinic acetylcholine receptors (nAChRs). The carbamate functionality and a small hydrophobic substituent in the C-3 position were found to be vital for the binding affinity to the nAChRs, whereas the carbamate nitrogen substituents were important for nAChR subtype selectivity. Finally, the compounds were found to be agonists at the α3β4 nAChR.