112063-63-5

Basic information

• Product Name: 4-(4-Benzoyl-piperazin-1-yl)-N-(4aS,5S,11aS)-1,2,3,4,4a,5,11,11a-octahydro-10-thia-dibenzo[a,d]cyclohepten-5-yl-butyramide
• CAS NO: 112063-63-5
• Molecular Weight: 491.698
• Mol File: 112063-63-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-Benzoyl-piperazin-1-yl)-N-(4aS,5S,11aS)-1,2,3,4,4a,5,11,11a-octahydro-10-thia-dibenzo[a,d]cyclohepten-5-yl-butyramide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Benzoyl-piperazin-1-yl)-N-(4aS,5S,11aS)-1,2,3,4,4a,5,11,11a-octahydro-10-thia-dibenzo[a,d]cyclohepten-5-yl-butyramide(112063-63-5)
• EPA Substance Registry System: 4-(4-Benzoyl-piperazin-1-yl)-N-(4aS,5S,11aS)-1,2,3,4,4a,5,11,11a-octahydro-10-thia-dibenzo[a,d]cyclohepten-5-yl-butyramide(112063-63-5)

Safety Data

• Hazardous Substances Data: 112063-63-5(Hazardous Substances Data)

Upstream product

• 130982-55-7 trans(6a-H,10a-H)-cis(10a-H,11-H)-11-amino-6,6a,7,8,9,10,10a,11-octahydrodibenzothiepine 
• 130982-63-7 (6aR^*,10aR^*,11R^*)-11-<(chlorobutyryl)amino>-6,6a,7,8,9,10,10a,11-octahydrodibenzothiepin 
• 13754-38-6 N-Benzoylpiperazine 

Relevant articles and documents

A New Class of Calcium Antagonists. Synthesis and Biological Activity of 11--6,6a,7,8,9,10,10a,11-octahydrodibenzothiepin Derivatives

A series of 11--6,6a,7,8,9,10,10a,11-octahydrodibenzothiepin derivatives were prepared and found to be structurally new class of calcium antagonists.The structure-activivty relationship studies indicated that the optimum was (6aR*,10aR*,11R*)-11-butyryl>amino>-6,6a,7,8,9,10,10a,11-octahydrodibenzothiepin (31, pA2 8.16), which was superior to diltiazem (pA2 7.42) in calcium antagonistic activity.Compound 31 showed antihypertensive activity in anesthetized rats, without a significant effect on the heart rate.It had also antianginal effects in vasopressin-induced ST-elevation testings in rats.These potencies of 31 were essentially equal to those of diltiazem.