112080-30-5Relevant articles and documents
The Biginelli condensation: A novel and efficient regioselective synthesis of dihydropyrimidin-2(1H)-ones using lithium bromide
Baruah, Partha P.,Gadhwal, Sunil,Prajapati, Dipak,Sandhu, Jagir S.
, p. 1038 - 1039 (2002)
Various substituted 3,4-dihydropyrimidin-2(1H)-ones were synthesised in one-pot reaction of aldehydes, β-ketoesters and urea using LiBr in tetrahydrofuran in excellent yields without any side reactions as observed by Biginelli and others.
Highly versatile solid phase synthesis of biofunctional 4-aryl-3,4- dihydropyrimidines using resin-bound isothiourea building blocks and multidirectional resin cleavage
Kappe, C. Oliver
, p. 49 - 51 (2007/10/03)
A series of pharmacologically active, functionalized 4-aryl-3,4- dihydropyrimidine-5-carboxylates (DHPMs) are prepared by a versatile novel solid phase approach. In the key step, a polymer-bound thiouronium salt is condensed with unsaturated β-ketoesters. The resulting polymer bound 1,4- dihydropyrimidines are cleaved from the resin employing multidirectional resin cleavage strategies.
Microwave-assisted high-speed parallel synthesis of 4-aryl-3,4- dihydropyrimidin-2(1H)-ones using a solventless biginelli condensation protocol
Kappe, C. Oliver,Kumar, Dalip,Varma, Rajender S.
, p. 1799 - 1803 (2007/10/03)
4-Aryl-3,4-dihydropyrimidin-2-(1H)-ones 4a-o are synthesized by a microwave-promoted, solvent-free modification of the Biginelli three- component cyclocondensation reaction. The novel method employs neat mixtures of β-ketoesters, aryl aldehydes, and urea
