1121-03-5Relevant articles and documents
1, 3-propane sultone methyl fluoro derivative as well as preparation method and application thereof
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Paragraph 0022-0030, (2021/09/26)
The invention relates to a preparation method of a 1, 3-propane sultone methyl fluoro derivative, which comprises the following steps: 1) taking 3-butene-2-alcohol and sodium hydrogen sulfite as raw materials, taking peroxide as an initiator, carrying out addition reaction in an ammonia water solution, after full reaction, reducing pressure, heating and concentrating until the material is thick, and acidizing by using concentrated hydrochloric acid, cooling to room temperature, filtering and concentrating filtrate to be viscous, transferring the concentrated filtrate into a vacuum reaction kettle, continuously flash-evaporating, dehydrating and cyclizing under a high-temperature vacuum condition, and rectifying a crude product to obtain 3-methyl-PS; and 2) preparing the methyl fluoro derivative: fully mixing 3-methyl-PS with dichloromethane, adding a fluorinating agent, fully reacting, and removing dichloromethane under reduced pressure to obtain the methyl fluoro derivative. The preparation method has the advantages that 3-methyl-PS is successfully prepared, the 3-methyl-PS can be directly fluorinated, the product structure is clear and single, no by-product is generated, and the methyl fluoro derivative has an obvious effect of enhancing the performance of a lithium battery when being used as an electrolyte additive of the lithium battery.
Synthesis of a series of sulfinic acid analogs of GABA and evaluation of their GABA(B) receptor affinities
Carruthers, Nicholas I.,Spitler, James M.,Wong, Shing-Chun,Blythin, David J.,Chen, Xiao,Shue, Ho-Jane,She, Hoyan S.,Lee, Joe F.,Rizzo, Charles,Ting, Pauline C.,West Jr., Robert E.
, p. 3059 - 3064 (2007/10/03)
A series of γ-aminobutyric acid (GABA) 1 analogs was prepared in which the carboxylic acid group of GABA was replaced with a sulfinic acid group and their affinity for the GABA(B) receptor investigated.
SYNTHESIS OF γ- AND δ-SULTONES FROM THE PRODUCTS OF CHLOROSULFONATION OF 1-CHLOROBUTANE
Kurdyukov, A. M.,Khardin, A. P.,Komyakov, Yu. A.
, p. 526 - 530 (2007/10/02)
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