112154-51-5

Basic information

• Product Name: 5'-O-(4,4'-dimethoxytrityl)-3'-O-(2,2,2-trichloroethoxycarbonyl)-N²-isobutyryldeoxyguanosine
• CAS NO: 112154-51-5
• Molecular Weight: 815.107
• Mol File: 112154-51-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5'-O-(4,4'-dimethoxytrityl)-3'-O-(2,2,2-trichloroethoxycarbonyl)-N²-isobutyryldeoxyguanosine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(4,4'-dimethoxytrityl)-3'-O-(2,2,2-trichloroethoxycarbonyl)-N²-isobutyryldeoxyguanosine(112154-51-5)
• EPA Substance Registry System: 5'-O-(4,4'-dimethoxytrityl)-3'-O-(2,2,2-trichloroethoxycarbonyl)-N²-isobutyryldeoxyguanosine(112154-51-5)

Safety Data

• Hazardous Substances Data: 112154-51-5(Hazardous Substances Data)

Upstream product

• 68892-41-1 5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine 
• 17341-93-4 2,2,2-Trichloroethyl chloroformate 

Downstream Products

• 112154-52-6 5'-O-(4,4'-dimethoxytrityl)-N²-isobutyryl-N¹,N²-bis(isobutyryloxy)ethylenedeoxyguanosine 
• 112154-53-7 N₂-isobutyryl-1,N₂-[1,2-di(isobutyryloxy)ethylene]-3',5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine 

Relevant articles and documents

Solid Phase Synthesis of Oligodeoxyribonucleotides Utilizing the Phenylthio Group as a Phosphate Protecting Group

Oligodeoxyribonucleotide synthesis utilizing the phenylthio group as a phosphate protecting group was applied to the solid phase method.The base residues of deoxyguanosine and deoxyadenosine were protected with bis(isobutyryloxy)ethylene (Bibe) and phthaloyl groups to avoid the base modfication and depurination, respectively.A key synthetic intermediate of N2-isobutyryl-N1,N2-bis(isobutyryloxy)ethylenedeoxyguanosine was prepared in high yield by four-step reaction from deoxyguanosine and used for preparation of the building blocks of deoxyguanosine required for the polymer support synthesis.Two kinds of polymer supports, i.e., 1 percent cross-linked polystyrene and controlled pore glass were chosen.The latter was employed for the synthesis of dodecadeoxyribonucleotides by using an automated DNA synthesizer.