112175-38-9Relevant articles and documents
Quinolinones as Inhibitors of Translation Initiation Complex
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, (2018/03/25)
Provided herein are compounds and pharmaceutical compositions comprising quinolinones. The quinolinones and compositions thereof are useful as eukaryotic translation initiation factor 4F (eIF4F) complex modulators.
Design, synthesis, and structure-activity relationships of aminopyridine N-oxides, a novel scaffold for the potent and selective inhibition of p38 mitogen activated protein kinase
Lumeras, Wenceslao,Caturla, Francisco,Vidal, Laura,Esteve, Cristina,Balagué, Cristina,Orellana, Adelina,Domínguez, María,Roca, Ramón,Huerta, Josep M.,Godessart, Núria,Vidal, Bernat
experimental part, p. 5531 - 5545 (2010/02/28)
A novel series of aminopyridine N-oxides were designed, synthesized, and tested for their ability to inhibit p38α MAP kinase. Some of these compounds showed a significant reduction in the LPS-induced TNFR production in human whole blood. Structure-activit
Synthesis of aza analogues of the anticancer agent batracylin
Martínez-Viturro, Carlos M.,Domínguez, Domingo
, p. 4707 - 4710 (2008/03/13)
Three series of pyrido-fused pyrimido[2,1-a]isoindol-7-ones were prepared from readily available (aminopyridinyl)(aryl)methanones by reduction followed by a Mitsunobu reaction with phthalimide and acid-catalysed cyclodehydration. This approach provides a wide variety of aza analogues of the antitumour agent batracylin.