112211-72-0Relevant articles and documents
Ring expansion of cyclic β-amino alcohols induced by diethylaminosulfur trifluoride: Synthesis of cyclic amines with a tertiary fluorine at C3
Anxionnat, Bruno,Robert, Benoit,George, Pascal,Ricci, Gino,Perrin, Marc-Antoine,Gomez Pardo, Domingo,Cossy, Janine
experimental part, p. 6087 - 6099 (2012/09/11)
As the replacement of a hydrogen atom by a fluorine atom in a compound can have an important impact on its biological properties, the development of methods allowing the introduction of a fluorine atom is of great importance. The scope and limitations of
DBU-Catalyzed Deconjugation of 7-Substituted 3,4-Didehydro-2-oxepanones. Deuterium Incorporation, Significance of the Imine Double Bond, and Application to the Synthesis of a Key Pharmacophore
Jeyaraj, Duraiswamy A.,Kapoor, Kamal K.,Yadav, Veejendra K.,Gauniyal, Harsh M.,Parvez, Masood
, p. 287 - 294 (2007/10/03)
7-Substituted 3,4-Didehydro-2-oxepanones are conveniently deconjugated to the 4,5-didehydro derivatives by DBU. The isomerization of 7-benzyl-substituted 2-oxepanones proceeds to the extent of 90% over the initial 3 h; the concentration falls gradually thereafter to achieve, in 25 h, a 3:2 equilibrium in favor of deconjugation. Such an equilibrium does not exist for the 7-methyl and the 7-(2-phenethyl) derivatives. The significance of the imine double bond in DBU has been explored. The isomerization in CDCl3 causes deuterium incorporation at positions 3 and 5 of the 2-oxepanones examined and at position 6 of DBU. The mechanistic rationales for these deuterium incorporations are advanced. The transformation of 7-benzyl-3,4-didehydro-2-oxepanone into a bicyclo[3.3.0] skeleton that is present in a diverse class of biologically active natural products is described as a possible potential use of the present deconjugation methodology.
Cyano or Acyl Group Migration by Consecutive Homolytic Addition and β-Fission
Beckwith, Athelstan L. J.,O'Shea, Dennis M.,Gerba, Sendaba,Westwood, Steven W.
, p. 666 - 667 (2007/10/02)
Suitably constituted aryl and alkyl radicals readily rearrange by 1,2- or 1,4-acyl or cyano migration.