112212-94-9Relevant articles and documents
C(sp3)?H Cyanation Promoted by Visible-Light Photoredox/Phosphate Hybrid Catalysis
Wakaki, Takayuki,Sakai, Kentaro,Enomoto, Takafumi,Kondo, Mio,Masaoka, Shigeyuki,Oisaki, Kounosuke,Kanai, Motomu
, p. 8051 - 8055 (2018)
Inspired by the reaction mechanism of photo-induced DNA cleavage in nature, a C(sp3)?H cyanation reaction promoted by visible-light photoredox/phosphate hybrid catalysis was developed. Phosphate radicals, generated by one-electron photooxidation of phosphate salt, functioned as a hydrogen-atom-transfer catalyst to produce nucleophilic carbon radicals from C(sp3)?H bonds with a high bond-dissociation energy. The resulting carbon radicals were trapped by a cyano radical source (TsCN) to produce the C?H cyanation products. Due to the high functional-group tolerance and versatility of the cyano group, the reaction will be useful for realizing streamlined building block syntheses and late-stage functionalization of drug-like molecules.
Spiro Derivatives of Tetrahydrothiophene. Synthesis of the Quinolizidinetetrahydrothiophene System Using Solid/Liquid or Liquid/Liquid Phase-Transfer Catalysis
Wrobel, Jerzy T.,Hejchman, Elzbieta
, p. 452 - 455 (2007/10/02)
4-Oxooctahydroquinolizinetetrahydrothiophene 1',1'-dioxide can be synthetized from 2-cyanotetrahydrothiophene by two independent routes, both of them using phase-transfer catalysis: the first one involves alkylation of 2-cyanotetrahydrothiphen
