112272-69-2Relevant articles and documents
Hydrolysis of carboxylate and phosphate esters using monopyridinium oximes in cationic micellar media
Singh, Namrata,Ghosh, Kallol K.,Marek, Jan,Kuca, Kamil
experimental part, p. 569 - 578 (2012/01/14)
The reactions of p-nitrophenyl acetate (PNPA) with a series of monopyridinium oximes, viz. 2-PAM (2-hydroxyiminomethyl-1-methylpyridinium iodide), 3-PAM (3-hydroxyiminomethyl-1-methylpyridinium iodide), and 4-PAM (4-hydroxyiminomethyl-1-methylpyridinium iodide) have been studied in the presence of cationic surfactants of same hydrophobic chain length (C 16) within the concentration range of 0.5-6.0 mM at pH 8.0 under the pseudo-first-order condition. The observed rate constant (kobs) increases with increasing surfactant concentration culminating into a maximum, and this has been analyzed in detail following the concepts of micellar catalysis. The structure-activity relationship of the investigated oximes has been discussed, and 2-PAM was found to be the most reactive among all the three investigated oximes for the cleavage of PNPA. Esterolytic decomposition of p-nitrophenyldiphenyl phosphate with oximate ions (-CH=NO-) was followed in cetyltrimethylammonium bromide micelles at pH 9.0, and 4-PAM was the most reactive oxime for the micellar hydrolysis of phosphate ester. The apparent acid dissociation constants (pKa) of the investigated oximes have been determined spectrophotometrically.