112299-62-4

Basic information

• Product Name: 1-Bromo-3-(bromomethyl)-2-methylBenzene
• Synonyms: 1-Bromo-3-(bromomethyl)-2-methylBenzene;1-Bromo-2-methyl-3-(bromomethyl)benzene;1-Bromo-3-(bromomethyl)-2-methylbenzene, alpha,3-Dibromo-o-xylene;3-Bromo-2-methylbenzyl bromide 97%;3-Bromo-2-methylbenzylbromide97%;3-Bromo-2-methylbenzyl bromide;Benzene, 1-bromo-3-(bromomethyl)-2-methyl-
• CAS NO: 112299-62-4
• Molecular Formula: C₈H₈Br₂
• Molecular Weight: 263.959
• Mol File: 112299-62-4.mol
• Article Data: 19

Chemical Properties

• Melting Point: 31-32℃
• Boiling Point: 279℃
• Flash Point: 139℃
• Appearance: /
• Density: 1.743
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.595
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Bromo-3-(bromomethyl)-2-methylBenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-3-(bromomethyl)-2-methylBenzene(112299-62-4)
• EPA Substance Registry System: 1-Bromo-3-(bromomethyl)-2-methylBenzene(112299-62-4)

Safety Data

• Hazardous Substances Data: 112299-62-4(Hazardous Substances Data)

Usage

General Description

1-Bromo-3-(bromomethyl)-2-methylBenzene, also known as 1,3-dibromo-2-methylbenzene, is a chemical substance belonging to the class of organic compounds known as aromatic halides. Its molecular formula is C8H8Br2. 1-Bromo-3-(bromomethyl)-2-methylBenzene plays a significant role in various chemical reactions due to its two bromide atoms. Aromatic halides like this compound are commonly used in various industries, particularly in pharmacology, agrochemicals, dyes, and polymers, due to their potential to undergo several types of reactions. 1-Bromo-3-(bromomethyl)-2-methylBenzene, with its specific structural elements, may pose toxicity risks, and proper procedures should be followed for its handling and disposal. The information about its physical properties, safety measures, and comprehensive data including its reactiveness with various other compounds are usually provided by suppliers or can be found in material safety data sheets.

InChI:InChI=1/C8H8Br2/c1-6-7(5-9)3-2-4-8(6)10/h2-4H,5H2,1H3

Upstream product

• 83647-43-2 3-bromo-2-methylbenzyl alcohol 
• 52780-15-1 3'-bromo-2'-methylbenzonitrile 
• 103038-43-3 3-bromo-2-methyl-benzoic acid ethyl ester 
• 76006-33-2 3-bromo-2-methylbenzoic acid 
• 576-23-8 2,3-dimethylbromobenzene 
• 99548-54-6 methyl 3-bromo-2-methylbenzoate 
• 83647-40-9 3-bromo-2-methylbenzaldehyde 
• 69321-60-4 2,6-dibromotoluene 

Relevant articles and documents

Addition of Fluorine and a Late-Stage Functionalization (LSF) of the Oral SERD AZD9833

Herein we describe our efforts using a late stage functionalization together with more traditional synthetic approaches to generate fluorinated analogues of the clinical candidate AZD9833. The effects of the addition of fluorine on the lipophilicity, permeability, and metabolism are discussed. Many of these changes were tolerated in terms of pharmacology and resulted in high quality molecules which reached advanced stages of profiling in the testing cascade.

Novel biphenyl derivative as well as preparation method and medical application thereof

The invention relates to the field of medicinal chemistry, and discloses biphenyl derivatives with PD-1/PD-L1 inhibitory activity as well as a preparation method and application of the biphenyl derivatives. The invention further discloses a composition containing the biphenyl derivative with the PD-1/PD-L1 inhibitory activity or the pharmaceutically acceptable salt of the biphenyl derivative and a pharmaceutically acceptable carrier of the biphenyl derivative, and application of the biphenyl derivative in preparation of a PD-1/PD-L1 inhibitor. The compound can be used for treating tumors.

Enantioselective Intermolecular C-H Amination Directed by a Chiral Cation

The enantioselective amination of C(sp3)-H bonds is a powerful synthetic transformation yet highly challenging to achieve in an intermolecular sense. We have developed a family of anionic variants of the best-in-class catalyst for Rh-catalyzed C-H amination, Rh2(esp)2, with which we have associated chiral cations derived from quaternized cinchona alkaloids. These ion-paired catalysts enable high levels of enantioselectivity to be achieved in the benzylic C-H amination of substrates bearing pendant hydroxyl groups. Additionally, the quinoline of the chiral cation appears to engage in axial ligation to the rhodium complex, providing improved yields of product versus Rh2(esp)2 and highlighting the dual role that the cation is playing. These results underline the potential of using chiral cations to control enantioselectivity in challenging transition-metal-catalyzed transformations.