1124197-58-5

Basic information

• Product Name: Fluconazole-D4
• Synonyms: Fluconazole-d4;[2H4]-Fluconazole;Fluconazole-(dimethylene-d4);1,1,3,3-tetradeuterio-2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol
• CAS NO: 1124197-58-5
• Molecular Formula: C13H8D4F2N6O
• Molecular Weight: 310.295433512
• Product Categories: Aromatics, Heterocycles, Pharmaceuticals, Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1124197-58-5.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Fluconazole-D4(CAS DataBase Reference)
• NIST Chemistry Reference: Fluconazole-D4(1124197-58-5)
• EPA Substance Registry System: Fluconazole-D4(1124197-58-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 1124197-58-5(Hazardous Substances Data)

Usage

Description

Fluconazole-D4 is a deuterated analog of the triazole antifungal agent fluconazole, characterized by the presence of deuterium atoms in its molecular structure. It is a white solid and is primarily used as an internal standard for the quantification of fluconazole by gas chromatography (GC) or liquid chromatography (LC) mass spectrometry. This allows for accurate measurement and analysis of fluconazole levels in various samples, such as biological fluids or pharmaceutical formulations.

Uses

Used in Pharmaceutical Industry:
Fluconazole-D4 is used as an internal standard for the quantification of fluconazole by GCor LC-MS, ensuring accurate and reliable measurements in pharmaceutical research and development, as well as quality control processes.
Used in Clinical Research:
Fluconazole-D4 serves as an internal standard in clinical studies, helping to determine the pharmacokinetics, bioavailability, and efficacy of fluconazole as an antifungal agent in treating various fungal infections.
Used in Antifungal Applications:
Fluconazole-D4 is used as an antifungal agent, effective against most Candida strains and demonstrating protective activity in experimental animal models of systemic fungal diseases, including aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, cryptococcosis, and histoplasmosis.
Used in Analytical Chemistry:
Fluconazole-D4 is utilized as a reference compound in the development and validation of analytical methods for the detection and quantification of fluconazole in various matrices, such as environmental, food, and biological samples.