112696-91-0 Usage
Description
2-METHYL-N1-[4-(3-PYRIDINYL)-2-PYRIMIDINYL]-1,4-BENZENEDIAMINE is an organic compound with a dark yellow to orange solid appearance. It is characterized by its unique chemical structure, which includes a methyl group, a pyridine ring, and a pyrimidine ring attached to a benzene ring with two amine groups. 2-METHYL-N1-[4-(3-PYRIDINYL)-2-PYRIMIDINYL]-1,4-BENZENEDIAMINE serves as an intermediate in the preparation of Imatinib impurities, which are related to the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
2-METHYL-N1-[4-(3-PYRIDINYL)-2-PYRIMIDINYL]-1,4-BENZENEDIAMINE is used as an intermediate in the synthesis of Imatinib impurities. Imatinib, a tyrosine kinase inhibitor, is a widely used drug for the treatment of various cancers, including chronic myeloid leukemia and gastrointestinal stromal tumors. The compound plays a crucial role in the development and production of these impurities, which are essential for the quality control and safety assessment of the final drug product.
Used in Chemical Research:
As a complex organic molecule with unique structural features, 2-METHYL-N1-[4-(3-PYRIDINYL)-2-PYRIMIDINYL]-1,4-BENZENEDIAMINE can also be utilized in chemical research for the exploration of new synthetic pathways, the development of novel chemical reactions, and the investigation of its potential applications in various fields, such as materials science, catalysis, and drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 112696-91-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,6,9 and 6 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 112696-91:
(8*1)+(7*1)+(6*2)+(5*6)+(4*9)+(3*6)+(2*9)+(1*1)=130
130 % 10 = 0
So 112696-91-0 is a valid CAS Registry Number.
InChI:InChI=1/C16H15N5/c1-11-9-13(17)4-5-14(11)20-16-19-8-6-15(21-16)12-3-2-7-18-10-12/h2-10H,17H2,1H3,(H,19,20,21)
112696-91-0Relevant articles and documents
Live-cell imaging and profiling of c-Jun N-terminal kinases using covalent inhibitor-derived probes
Qian, Linghui,Pan, Sijun,Lee, Jun-Seok,Ge, Jingyan,Li, Lin,Yao, Shao Q.
, p. 1092 - 1095 (2019)
c-Jun N-terminal kinases (JNKs) are involved in critical cellular functions. Herein, small-molecule JNK-targeting probes are reported based on a covalent inhibitor. Together with newly developed two-photon fluorescence Turn-ON reporters and chemoproteomic studies, we showed that some probes may be suitable for live-cell imaging and profiling of JNKs.
N-PHENYL-2-PYRIMIDINE-AMINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF
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Page 25, (2010/02/09)
The present invention relates to an N-phenyl-2-pyrimidine-amine derivative showing a superior effect on tumor, lung cancer, gastric cancer, etc. of warm-blooded animals and its salt. The present invention also relates to a process for preparing the compound and a pharmaceutical composition for the prevention and treatment of such diseases as tumor, lung cancer, gastric cancer, etc., which comprises the compound as an active ingredient.
