1127440-83-8

Basic information

• Product Name: 1,1-dimethylethyl (2R,6S)-4-([4-(2-(4-[(4-fluorophenyl)amino]-1-piperidinyl)-1-methyl-2-oxoethyl)phenyl]methyl)-2,6-dimethyl-1-piperazinecarboxylate
• CAS NO: 1127440-83-8
• Molecular Weight: 552.733
• Mol File: 1127440-83-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,1-dimethylethyl (2R,6S)-4-([4-(2-(4-[(4-fluorophenyl)amino]-1-piperidinyl)-1-methyl-2-oxoethyl)phenyl]methyl)-2,6-dimethyl-1-piperazinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-dimethylethyl (2R,6S)-4-([4-(2-(4-[(4-fluorophenyl)amino]-1-piperidinyl)-1-methyl-2-oxoethyl)phenyl]methyl)-2,6-dimethyl-1-piperazinecarboxylate(1127440-83-8)
• EPA Substance Registry System: 1,1-dimethylethyl (2R,6S)-4-([4-(2-(4-[(4-fluorophenyl)amino]-1-piperidinyl)-1-methyl-2-oxoethyl)phenyl]methyl)-2,6-dimethyl-1-piperazinecarboxylate(1127440-83-8)

Safety Data

• Hazardous Substances Data: 1127440-83-8(Hazardous Substances Data)

Upstream product

• 923566-02-3 C₂₁H₃₂N₂O₄ 
• 38043-08-2 4-(4-fluorophenylamino)-piperidine 

Relevant articles and documents

Discovery of N-(3-fluorophenyl)-1-[(4-([(35)-3-methyl-1-piperazinyl]methyl) phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate

N-(3-Fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl) acetyl]-4-piperidinamine 12 (GSK962040) is a novel small molecule motilin receptor agonist. It possesses excellent activity at the recombinant human motilin receptor and also at the native rabbit motilin receptor where its agonist activity results in potentiation of the amplitude of neuronal-mediated contractions of isolated gastric antrum tissue. Compound 12 also possesses highly promising pharmacokinetic profiles in both rat and dog, and these results, in combination with further profiling in human native tissue and an in vivo model of gastrointestinal transit in the rabbit, have led to its selection as a candidate for further development.