1128-44-5

Basic information

• Product Name: 1H-Indole-2,3-dione,4-methyl-
• Synonyms: Indole-2,3-dione,4-methyl- (7CI,8CI); Isatin, 4-methyl- (6CI); 4-Methylindole-2,3-dione;4-Methylindoline-2,3-dione; 4-Methylisatin
• CAS NO: 1128-44-5
• Molecular Formula: C₉H₇NO₂
• Molecular Weight: 161.159
• Mol File: 1128-44-5.mol
• Article Data: 15

Chemical Properties

• Melting Point: 189 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.301g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.77±0.20(Predicted)
• CAS DataBase Reference: 1H-Indole-2,3-dione,4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-2,3-dione,4-methyl-(1128-44-5)
• EPA Substance Registry System: 1H-Indole-2,3-dione,4-methyl-(1128-44-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1128-44-5(Hazardous Substances Data)

Usage

General Description

1H-Indole-2,3-dione,4-methyl-, also known as 4-methylisatin, is a chemical compound with the molecular formula C9H7NO2. It constitutes of an indole group, which is a heterocyclic aromatic organic compound, combined with a 2,3-dione group and a methyl group attached at the 4th position. It is generally used in the field of organic synthesis and pharmaceutical chemistry. However, the specifics about its properties such as boiling point, melting point, density, refractive index, flash point, and even its potential applications or risks to health or environment are not well-documented and may vary based on its form and usage.

InChI:InChI=1/C9H7NO2/c1-5-2-3-6-7(4-5)10-9(12)8(6)11/h2-4H,1H3,(H,10,11,12)

Upstream product

• 131543-46-9 Glyoxal 
• 108-44-1 1-amino-3-methylbenzene 
• 16096-32-5 4-methyl-1H-indole 
• 1388057-45-1 C₉H₇Br₂NO 
• 1189052-03-6 6-methyl-2-nitro-1-[2-iodoethynyl]benzene 
• 15219-34-8 Oxalyl bromide 
• 1132-29-2 2-hydroxyimino-N-m-tolylacetamide 
• 401585-34-0 oxalic acid-bis(3-tolylimidoyl)chloride 

Downstream Products

• 20877-81-0 5-methyl-1H-benzo[d][1,3]oxazine-2,4-dione 
• 1426932-16-2 C₁₆H₁₃NO₂ 
• 73271-41-7 N-methyl-3-(4-methylphenyl) isatin imine 
• 1608112-09-9 (Z)-4-methyl-3-(2-oxo-2-phenylethylidene)indolin-2-one 
• 4389-50-8 2-amino-6-methylbenzoic acid 

Relevant articles and documents

Counter-current chromatography separation of isatin derivatives using the sandmeyer methodology

A rapid and efficient method, using high-speed counter-current chromatography (HSCCC) technique, was developed for the separation of isomeric isatin derivatives, prepared following the Sandmeyer route. The biphasic solvent system composed of hexane:ethyl acetate:ethanol:water 1:0.5:0.5:1 (v/v/v/v) was used for all separations.

Excitation-wavelength-dependent photoluminescence of silicon nanoparticles enabled by adjustment of surface ligands

We herein present pioneering studies to reveal that excitation-wavelength-dependent photoluminescence properties of fluorescent silicon nanoparticles (SiNPs) can be realized by rationally designing surface ligands, i.e., several kinds of oxidized indole d

Method for preparing indole-2,3-dione derivatives by catalytic oxidation of microwave copper/peroxyacetic acid

The invention discloses a method for preparing indole-2,3-dione derivatives by catalytic oxidation of microwave copper/peroxyacetic acid. The method comprises the following steps: a catalytic amount of catalyst copper iodide, indole, a derivative of the indole and peroxyacetic acid are added into a reaction vessel, wherein the indole, the derivative of the indole and the peroxyacetic acid are usedas raw materials, ethanol is used as a solvent, the reaction vessel is placed into a microwave reaction instrument, a reaction is performed at certain temperature and power, after a certain time, reduced-pressure concentration is performed, and a product is purified by column chromatography. The method provided by the invention is a method having novel raw materials, simple operation and high efficiency used for preparing a benzimidazole derivative; and compared with the prior art, the method provided by the invention has an obviously-accelerated reaction speed than that under conventional heating, mild reaction conditions, simple operation, a high yield, safety, low costs and environmental protection.

Synthesis of isatins by I2/TBHP mediated oxidation of indoles

An I2/TBHP mediated oxidation of commercially available indoles has been developed, which affords isatins in moderate to good yields.