112811-91-3Relevant articles and documents
A convenient synthesis of n-substituted 2,3-dihydro-3-oxoisothiazolo[5,4-b]pyridines in acidic conditions
Terauchi, Hideo,Tanitame, Akihiko,Tada, Keiko,Nishikawa, Yoshinori
, p. 1719 - 1734 (2007/10/03)
A novel and convenient synthesis of N-substituted 2,3-dihydro-3-oxoisothiazolo[5,4-b]pyridines which possess potent in vitro inhibitory activity against gastric (H+/K+)-ATPase is reported. Compared with the methods reported previously, the compounds were synthesized more readily in relatively high yields by conversion of N-substituted 2-(benzyl-, 1-phenylethyl-, and benzhydrylsulfinyl)nicotinamides (17d-l) in a diluted hydrochloric acid-methanol solution at room temperature.
