112888-43-4Relevant articles and documents
Synthesis of substituted benzylamino- and heterocyclylmethylamino carbodithioate derivatives of 4-(3H)-quinazolinone and their cytotoxic activity
Cao, Sheng-Li,Feng, Yu-Ping,Zheng, Xiao-Lin,Jiang, Yu-Yang,Zhang, Mei,Wang, Yue,Xu, Meng
, p. 250 - 254 (2006)
A new series of substituted benzylamino- and heterocyclylmethylamino carbodithioate derivatives of 4-(3H)-quinazolinone were synthesized via four steps starting from 2-amino-5-methyl-benzoic acid and initially screened against A-549 (human non-small cell
Synthesis and in vitro antitumor activity of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains
Cao, Sheng-Li,Feng, Yu-Ping,Jiang, Yu-Yang,Liu, Shi-Ying,Ding, Guo-Yu,Li, Run-Tao
, p. 1915 - 1917 (2005)
A series of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains were synthesized and tested for their in vitro antitumor activity against human myelogenous leukemia K562 cells. Among them, (3,4-dihydro-2-methyl-4- oxoquinazolin-6-yl)methyl 4-(4-fluorophenyl)piperazine-1-carbodithioate 8q exhibited significant inhibitory activity against K562 cells with IC 50 value of 0.5 μM.
Folic-acid antagonist for treating intestinal bacterial infection, preparation and application thereof
-
Paragraph 0030; 0036; 0043; 0044; 0045; 0046, (2019/04/27)
The invention relates to a folic-acid antagonist for treating intestinal bacterial infection, preparation and an application thereof. The folic-acid antagonist is a compound as shown in Formula I or asalt of the compound as shown in Formula I (the Formula