112981-50-7

Basic information

• Product Name: Methanesulfonic acid, trifluoro-, 2-methoxyethyl ester
• CAS NO: 112981-50-7
• Molecular Formula: C4H7F3O4S
• Molecular Weight: 208.158
• Mol File: 112981-50-7.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Methanesulfonic acid, trifluoro-, 2-methoxyethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Methanesulfonic acid, trifluoro-, 2-methoxyethyl ester(112981-50-7)
• EPA Substance Registry System: Methanesulfonic acid, trifluoro-, 2-methoxyethyl ester(112981-50-7)

Safety Data

• Hazardous Substances Data: 112981-50-7(Hazardous Substances Data)

Upstream product

• 109-86-4 2-methoxy-ethanol 
• 358-23-6 trifluoromethylsulfonic anhydride 

Downstream Products

• 1449761-20-9 rac-tert-butyl N-(diphenylmethylene)-O-methylhomoserinate 
• 1027002-86-3 (7S,8R,9R)-7-cyclopropyl-7-(2-methoxyethoxy)-2-methyl-9-phenyl-8,9-dihydro-7H-imidazo[1,2-a]pyrano[2,3-c]pyridin-8-yl pivalate 
• 1027002-71-6 (7R,8R,9R)-7-(2-methoxyethoxy)-2,3,7-trimethyl-9-phenyl-8,9-dihydro-7H-imidazo[1,2-a]pyrano[2,3-c]pyridin-8-yl pivalate 
• 1027002-70-5 (7S,8R,9R)-7-(2-methoxyethoxy)-2,3,7-trimethyl-9-phenyl-8,9-dihydro-7H-imidazo[1,2-a]pyrano[2,3-c]pyridin-8-yl pivalate 
• 419566-18-0 (7R,8R,9R)-10-acetyl-7-(2-methoxyethoxy)-2-methyl-9-phenyl-8-pivaloyloxy-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine 

Relevant articles and documents

Regio- and stereoselective 1,2-dihydropyridine alkylation/addition sequence for the synthesis of piperidines with quaternary centers

The first example of C alkylation of 1,2-dihydropyridines with alkyl triflates and Michael acceptors was developed to introduce quaternary carbon centers with high regio- and diastereoselectivity. Hydride or carbon nucleophile addition to the resultant iminium ion also proceeded with high diastereoselectivity. Carbon nucleophile addition results in an unprecedented level of substitution to provide piperidine rings with adjacent tetrasubstituted carbon atoms. Pipe up: Alkylation of readily prepared 1,2-dihydropyridines with alkyl triflates and Michael acceptors introduces quaternary carbon centers with high regio- and diastereoselectivity. Hydride or carbon nucleophile addition to the resultant iminium ion also proceeds with high diastereoselectivity. For carbon nucleophile addition, an unprecedented level of substitution is achieved to provide piperidine rings with contiguous tetrasubstituted carbon atoms.

RAPAMYCIN ANALOGS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

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