113020-21-6

Basic information

• Product Name: 1,1-Cyclopropanedicarboxylic acid monomethyl ester
• Synonyms: Cyclopropane-1,1-dicarboxylic acid Monoethyl ester;Cyclopropane-1,1-dicarboxylicacid,Methy;CYCLOPROPANE-1,1-DICARBOXYLIC ACID, METHYL ESTER;1,1-CYCLOPROPANEDICARBOXYLIC ACID MONOMETHYL ESTER;1,1-CYCLOPROPANEDICARBOXYLIC ACID-1-METHYL ESTER;1,1-Cyclopropanedicarboxylicacid,monomethylester(9CI);1-(Methoxycarbonyl)cyclopropane-1-carboxylic acid;Cyclopropane-1,1-dicarboxylic acid monomethyl ester, 97%
• CAS NO: 113020-21-6
• Molecular Formula: C₆H₈O₄
• Molecular Weight: 144.13
• Product Categories: CARBOXYLICESTER;API intermediates
• Mol File: 113020-21-6.mol
• Article Data: 20

Chemical Properties

• Melting Point: 47-51°C
• Boiling Point: 85-87°C/0.2mm
• Flash Point: 104 °C
• Appearance: /
• Density: 1.419
• Vapor Pressure: 0.009mmHg at 25°C
• Refractive Index: 1.519
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.37±0.20(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 1,1-Cyclopropanedicarboxylic acid monomethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-Cyclopropanedicarboxylic acid monomethyl ester(113020-21-6)
• EPA Substance Registry System: 1,1-Cyclopropanedicarboxylic acid monomethyl ester(113020-21-6)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25-52
• Safety Statements: 45
• RIDADR: UN2811
• HazardClass: IRRITANT
• Hazardous Substances Data: 113020-21-6(Hazardous Substances Data)

Usage

Uses

1,1-Cyclopropanedicarboxylic acid monomethyl ester is used as a pharmaceutical intermediate.

InChI:InChI=1/C6H8O4/c1-10-5(9)6(2-3-6)4(7)8/h2-3H2,1H3,(H,7,8)

Upstream product

• 67-56-1 methanol 
• 34867-88-4 cyclopropane-1,1-dicarbonyl peroxide 
• 6914-71-2 dimethyl 1,1-cyclopropanedicarboxylate 
• 1559-02-0 diethyl cyclopropane-1,1-dicarboxylate 

Downstream Products

• 198760-31-5 (5Z,7E,22E)-(1S,3R,24R)-25-(5-butyloxazole-2-yl)-26,27-cyclo-9,10-secocholesta-5,7,10⁽¹⁹⁾,22-tetraene-1,3,24-triol 
• 918642-72-5 1-((4-fluorophenyl)(methyl)carbamoyl)cyclopropane-1-carboxylic acid 
• 6914-80-3 1-(aminocarbonyl)-1-cyclopropanecarboxylic acid methyl ester 
• 849217-77-2 1-({4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}carbamoyl)cyclopropane-1-carboxylic acid 
• 849217-68-1 cabozantinib 
• 1373611-15-4 methyl 1-[(4-methoxyphenyl)carbamoyl]cyclopropane-1-carboxylate 
• 1373611-14-3 methyl 1-(p-tolylcarbamoyl)cyclopropane-1-carboxylate 
• 1373611-16-5 methyl 1-[(4-chlorophenyl)carbamoyl]cyclopropane-1-carboxylate 

Relevant articles and documents

Spontaneous reaction of malonyl peroxides with methanol

The spontaneous reaction of disubstituted malonyl peroxides (MPOs) with methanol affording monopermalonic acid monomethyl esters is fast (minutes) for lower homologues but is sharply decelerated (days) for the higher ones. Spirocyclopropyl-MPO is an excep

Alcoholysis of malonyl peroxides to give peracids

Potassium acetate catalyzed alcoholysis of spirocycloalkyl malonyl peroxides affords 1-alkoxycarbonylcycloalkane-1-percarboxylic acids which are suitable for epoxidation of olefins.

PYRIDO-AZAHETERECYDIC COMPOUND AND PREPARATION METHOD AND USE THEREOF

The present invention discloses a pyrido-azacyclic compound represented by formula I, an isomer thereof, a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate thereof, a preparation process thereof and a composition comprising the compound, and a use thereof as a multi-target protein kinase inhibitor in the preparation of a medicament for the treatment of diseases that are associated with protein kinase, especially c-Met, such as cancer and the like. The compound represented by formula I has potent inhibitory activity on tumor cells with overexpression of c-Met kinase, can effectively target c-Met-mediated signaling pathway, and can be used in the treatment of diseases such as cancer and the like that is caused by the overexpression of c-Met kinase.