113136-80-4Relevant articles and documents
NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS
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Page/Page column 127; 128, (2020/10/09)
The present disclosure compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the TEAD transcription factor, and are useful in the treatment of diseases related to the activity of TEAD transcription factor including, e.g., cancer and other diseases.
Discovery of a highly potent, selective and novel CDK9 inhibitor as an anticancer drug candidate
Li, Yongtao,Guo, Qingxiang,Zhang, Chao,Huang, Zhi,Wang, Tianqi,Wang, Xin,Wang, Xiang,Xu, Guangwei,Liu, Yanhua,Yang, Shengyong,Fan, Yan,Xiang, Rong
supporting information, p. 3231 - 3237 (2017/07/07)
A series of novel hybrid structure derivatives, containing both LEE011 and Cabozantinib pharmacophore, were designed, synthesized and evaluated. Surprisingly, a compound 4d was discovered that highly exhibited effective and selective activity of CDK9 inhi