1131410-80-4Relevant articles and documents
DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: Synthesis and antibacterial activity
East, Stephen P.,White, Clara Bantry,Barker, Oliver,Barker, Stephanie,Bennett, James,Brown, David,Boyd, E. Andrew,Brennan, Christopher,Chowdhury, Chandana,Collins, Ian,Convers-Reignier, Emmanuelle,Dymock, Brian W.,Fletcher, Rowena,Haydon, David J.,Gardiner, Mihaly,Hatcher, Stuart,Ingram, Peter,Lancett, Paul,Mortenson, Paul,Papadopoulos, Konstantinos,Smee, Carol,Thomaides-Brears, Helena B.,Tye, Heather,Workman, James,Czaplewski, Lloyd G.
, p. 894 - 899 (2009)
The synthesis and antibacterial activities of three chemotypes of DNA supercoiling inhibitors based on imidazolo[1,2-a]pyridine and [1,2,4]triazolo[1,5-a]pyridine scaffolds that target the ATPase subunits of DNA gyrase and topoisomerase IV (GyrB/ParE) is reported. The most potent scaffold was selected for optimization leading to a series with potent Gram-positive antibacterial activity and a low resistance frequency.
