1132644-77-9Relevant articles and documents
Spiro-piperidine azetidinones as potent TRPV1 antagonists
Xiao, Dong,Palani, Anandan,Aslanian, Robert,McKittrick, Brian A.,McPhail, Andrew T.,Correll, Craig C.,Phelps, P. Tara,Anthes, John C.,Rindgen, Diane
scheme or table, p. 783 - 787 (2009/08/15)
A series of spiro-piperidine azetidinone were synthesized and evaluated as potential TRPV1 antagonists. An important issue of plasma stability was investigated and resolved. Further focused SAR study lead to the discovery of a potent antagonist with good