1132662-08-8 Usage
Description
CAPECITABINE-D11 is an isotopically labeled antineoplastic agent, serving as a prodrug of Doxifluridine. It is designed for use as an internal standard in the quantification of capecitabine by gas chromatography (GC) or liquid chromatography-mass spectrometry (LC-MS). Capecitabine is a prodrug form of 5-fluorouracil (5-FU), which is converted to 5-FU through several enzymatic steps, with the final conversion occurring in tumor tissue by thymidine phosphorylase, an enzyme more concentrated in tumor tissue than in normal tissue. CAPECITABINE-D11 exhibits cytotoxicity at high concentrations in specific cancer cell lines and is chemically characterized as an off-white powder.
Uses
Used in Pharmaceutical Research and Development:
CAPECITABINE-D11 is used as an internal standard for the quantification of capecitabine by GCor LC-MS, aiding in the accurate measurement and analysis of capecitabine levels in various pharmaceutical applications.
Used in Cancer Treatment:
As a prodrug of Doxifluridine, CAPECITABINE-D11 is utilized in cancer treatment, particularly for solid tumors. It is converted to the active metabolite 5-FU, which inhibits tumor growth by interfering with DNA and RNA synthesis.
Used in Drug Development and Quality Control:
CAPECITABINE-D11 serves as a valuable tool in drug development and quality control processes, ensuring the efficacy, safety, and consistency of capecitabine-based medications.
Used in Cancer Cell Line Research:
CAPECITABINE-D11 is used in the study of specific cancer cell lines, such as Scaber, SIHA, and MKN45, to evaluate its cytotoxic effects and potential applications in targeted cancer therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 1132662-08-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,3,2,6,6 and 2 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1132662-08:
(9*1)+(8*1)+(7*3)+(6*2)+(5*6)+(4*6)+(3*2)+(2*0)+(1*8)=118
118 % 10 = 8
So 1132662-08-8 is a valid CAS Registry Number.
