1132667-24-3

Basic information

• Product Name: C₄₉H₆₀N₄O₇S₃Si
• CAS NO: 1132667-24-3
• Molecular Weight: 941.322
• Mol File: 1132667-24-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₉H₆₀N₄O₇S₃Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₉H₆₀N₄O₇S₃Si(1132667-24-3)
• EPA Substance Registry System: C₄₉H₆₀N₄O₇S₃Si(1132667-24-3)

Safety Data

• Hazardous Substances Data: 1132667-24-3(Hazardous Substances Data)

Upstream product

• 1137735-74-0 (S,E)-2-(trimethylsilyl)ethyl 3-(((S)-2-amino-3-methylbutanoyl)oxy)-7-(tritylthio)hept-4-enoate 
• 1132667-22-1 (R)-2-(2-tert-butoxycarbonylaminomethyl-thiazol-4-yl)-4,5-dihydrothiazole-4-carboxylic acid 

Relevant articles and documents

Synthesis and histone deacetylase inhibitory activity of largazole analogs: Alteration of the zinc-binding domain and macrocyclic scaffold

Fourteen analogs of the marine natural product largazole have been prepared and assayed against histone deacetylases (HDACs) 1, 2, 3, and 6. Olefin cross-metathesis was used to efficiently access six variants of the side-chain zinc-binding domain, while adaptation of our previously reported modular synthesis allowed probing of the macrocyclic cap group.