1134365-97-1

Basic information

• Product Name: N,N-bis(4-methoxyphenyl)malonamic acid tert-butyl ester
• Synonyms: N,N-bis(4-methoxyphenyl)malonamic acid tert-butyl ester
• CAS NO: 1134365-97-1
• Molecular Weight: 371.433
• Mol File: 1134365-97-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N,N-bis(4-methoxyphenyl)malonamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-bis(4-methoxyphenyl)malonamic acid tert-butyl ester(1134365-97-1)
• EPA Substance Registry System: N,N-bis(4-methoxyphenyl)malonamic acid tert-butyl ester(1134365-97-1)

Safety Data

• Hazardous Substances Data: 1134365-97-1(Hazardous Substances Data)

Upstream product

• 40052-13-9 mono-tert-butyl malonate 
• 101-70-2 bis(4-methoxyphenyl)amine 

Downstream Products

• 1134366-27-0 (S)-2-benzyl-N,N-bis(4-methoxyphenyl)malonamic acid tert-butyl ester 
• 1134366-42-9 (S)-2-(4-methoxybenzyl)-N,N-bis(4-methoxyphenyl)malonamic acid tert-butyl ester 
• 1134366-39-4 (S)-2-(p-tolyl)-N,N-bis(4-methoxyphenyl)malonamic acid tert-butyl ester 
• 1134366-35-0 (S)-2-[bis(4-methoxyphenyl)carbamoyl]pent-4-enoic acid tert-butyl ester 
• 1134366-37-2 (S)-2-(4-fluorobenzyl)-N,N-bis(4-methoxyphenyl)malonamic acid tert-butyl ester 
• 1134366-46-3 (S)-2-naphthalen-β-yl-methyl-N,N-bis(4-methoxyphenyl)malonamic acid tert-butyl ester 
• 1134366-44-1 (S)-2-(4-nitrobenzyl)-N,N-bis(4-methoxyphenyl)malonamic acid tert-butyl ester 
• 1134366-31-6 (S)-2-methyl-N,N-bis(4-methoxyphenyl)malonamic acid tert-butyl ester 
• 1229652-68-9 (S)-2-[bis(4-methoxyphenyl)carbamoyl]-4-bromopent-4-enoic acid tert-butyl ester 
• 1229652-66-7 C₂₅H₃₁NO₇ 

Relevant articles and documents

Asymmetric synthesis and receptor activity of chiral simplified resiniferatoxin (sRTX) analogues as transient receptor potential vanilloid 1 (TRPV1) ligands

The chiral isomers of the two potent simplified RTX-based vanilloids, compounds 2 and 3, were synthesized employing highly enantioselective PTC alkylation and evaluated as hTRPV1 ligands. The analysis indicated that the R-isomer was the eutomer in binding affinity and functional activity. The agonism of compound 2R was comparable to that of RTX. Docking analysis of the chiral isomers of 3 suggested the basis for its stereospecific activity and the binding mode of 3R.

Asymmetric synthesis and receptor activity of chiral simplified resiniferatoxin (sRTX) analogues as transient receptor potential vanilloid 1 (TRPV1) ligands

The chiral isomers of the two potent simplified RTX-based vanilloids, compounds 2 and 3, were synthesized employing highly enantioselective PTC alkylation and evaluated as hTRPV1 ligands. The analysis indicated that the R-isomer was the eutomer in binding affinity and functional activity. The agonism of compound 2R was comparable to that of RTX. Docking analysis of the chiral isomers of 3 suggested the basis for its stereospecific activity and the binding mode of 3R.