113502-52-6

Basic information

• Product Name: 1-Keto Ketorolac
• Synonyms: 1-Keto Ketorolac;Ketorolac Related Compound C (20 mg) (5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-one);5-Benzoyl-2,3-dihydro-1H-pyrrolizin-1-one;Ketorolac EP IMpurity B;Ketorolac Related CoMpound C;5-benzoyl-2,3-dihydropyrrolizin-1-one
• CAS NO: 113502-52-6
• Molecular Formula: C14H11NO2
• Molecular Weight: 225.24264
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 113502-52-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 427.9±33.0 °C(Predicted)
• Appearance: /
• Density: 1.26±0.1 g/cm3(Predicted)
• PKA: -11.95±0.20(Predicted)
• CAS DataBase Reference: 1-Keto Ketorolac(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Keto Ketorolac(113502-52-6)
• EPA Substance Registry System: 1-Keto Ketorolac(113502-52-6)

Safety Data

• Hazardous Substances Data: 113502-52-6(Hazardous Substances Data)

Usage

Uses

Ketorolac impurity.

Upstream product

• 74103-06-3 Ketorolac 
• 77-86-1 2-amino-2-hydroxymethyl-1,3-propanediol 

Relevant articles and documents

FeCl3-catalyzed oxidative decarboxylation of aryl/heteroaryl acetic acids: Preparation of selected API impurities

There is an ever-increasing demand for impurity compounds for use in impurity profiling as regulatory agencies seek information during registration. Herein, we report the FeCl3-catalyzed oxidative decarboxylation of aryl- and heteroaryl acetic acids to the corresponding carbonyl compounds. A variety of useful aldehydes and ketones were prepared in a simple one-pot transformation by employing an environmentally benign, low-cost, and readily available iron salt. The utility of this method has been demonstrated by preparing five valuable API impurities including a multi-gram-scale synthesis of ketorolac impurity B for the first time. This journal is