113544-38-0

Basic information

• Product Name: methyl 2-(2-fluoro-4-biphenylyl)propionate
• CAS NO: 113544-38-0
• Molecular Weight: 258.292
• Mol File: 113544-38-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 2-(2-fluoro-4-biphenylyl)propionate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(2-fluoro-4-biphenylyl)propionate(113544-38-0)
• EPA Substance Registry System: methyl 2-(2-fluoro-4-biphenylyl)propionate(113544-38-0)

Safety Data

• Hazardous Substances Data: 113544-38-0(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 5104-49-4 fluorobiprofen 
• 113544-32-4 (R)-3-O-(2-(2-fluoro-4-biphenyl)propionyl)-1,2-O-isopropylidene-α-D-glucofuranose 
• 1201594-47-9 C₁₂H₁₆FNO₅S 
• 98-80-6 phenylboronic acid 

Downstream Products

• 5104-49-4 (S)-(+)-flurbiprofen 
• 5104-49-4 (R)-flurbiprofen 
• 5104-49-4 fluorobiprofen 
• 863224-97-9 (1R,2R,3R,6S)-4-hydroxy-4,7,7-trimethylbicyclo[4.1.0]hept-3-yl (2R)-2-fluoro-2-(3-fluoro-4-phenylphenyl)propionate 
• 863224-98-0 (1R,2R,3R,6S)-4-hydroxy-4,7,7-trimethylbicyclo[4.1.0]hept-3-yl (2S)-2-fluoro-2-(3-fluoro-4-phenylphenyl)propionate 
• 42771-82-4 2-(2-fluoro-4-biphenylyl)-2-methylmalonic acid 
• 1262801-25-1 C₂₇H₁₉FN₂O₄S 
• 1435359-89-9 4-{2'-fluoro-4'-[1-oxo-1-(3-(1,2,3,4-tetrahydroacridin-9-ylamino)propylamino)propan-2-yl]biphenyl-4-yloxy}butyl nitrate 
• 1435359-97-9 6-{2'-fluoro-4'-[1-oxo-1-(3-(1,2,3,4-tetrahydroacridin-9-ylamino)propylamino)propan-2-yl]biphenyl-4-yloxy}hexyl nitrate 
• 1435360-05-6 2-{2'-fluoro-4'-[1-oxo-1-(4-(1,2,3,4-tetrahydroacridin-9-ylamino)butylamino)propan-2-yl]biphenyl-4-yloxy}ethyl nitrate 
• 1435360-13-6 3-{2'-fluoro-4'-[1-oxo-1-(4-(1,2,3,4-tetrahydroacridin-9-ylamino)butylamino)propan-2-yl]biphenyl-4-yloxy}propyl nitrate 
• 1435360-21-6 4-{2'-fluoro-4'-[1-oxo-1-(4-(1,2,3,4-tetrahydroacridin-9-ylamino)butylamino)propan-2-yl]biphenyl-4-yloxy}butyl nitrate 
• 1435360-29-4 6-{2'-fluoro-4'-[1-oxo-1-(4-(1,2,3,4-tetrahydroacridin-9-ylamino)butylamino)propan-2-yl]biphenyl-4-yloxy}hexyl nitrate 
• 215175-84-1 methyl 2-(4′-acetoxy-2-fluoro-[1,1′-biphenyl]-4-yl)propanoate 

Relevant articles and documents

Resolution of racemic flurbiprofen by lipase-mediated esterification in organic solvent

Resolution of rac-flurbiprofen, 2-fluoro-α-methyl-[1,1'-biphenyl]-4-acetic acid (1), by biocatalytic methodologies has been studied. Enzymatic hydrolysis of rac-flurbiprofen methyl ester (2) in aqueous-organic medium gave poor results. Transesterification of the same ester mediated by immobilized lipase from Candida antarctica (Novozym 435) in organic solvent proceeded with good enantiomeric excess but the isolation of the product required chromographic separation and therefore was unsuitable for large scale preparation. Direct esterification of 1 with methanol in acetronitrile promoted by Novozym 435 proved to be the best method since it gave, via a twofold kinetic resolution, S-flurbiprofen with excellent enantiomeric excess. The R-flurbiprofen methyl ester formed in the reaction can be converted into the starting rac-flurbiprofen by alkaline hydrolysis or, alternatively, into R-flurbiprofen by hydrolysis with acid.

ESTERS OF ARYLPROPIONIC ACIDS WITH 1,2:5,6-DI-O-ISOPROPYLIDENE- AND 1,2-O-ISOPROLYLIDENE-α-D-GLUCOFURANOSE

On fractional crystallization of 3-O-(2-(2-fluoro-4-biphenylyl)propionyl-, 3-O-(2-(4-isobutylphenyl)propionyl)- and 3-O-(2-(6-methoxy-2-naphthyl)propionyl)-1,2:5,6-di-O-isopropylidene-α-D-glucofuranoses V - VII optically pure R-diastereoisomers were isolated.The derivatives of 1,2-O-isopropylidene-α-D-glucofuranose obtained on partial deacetylation of esters V - VII were separated chromatographically to R and S-diastereoisomers.Their hydrolysis or transesterification afforded optically pure arylpropionic acids or their methyl esters, respectively.Kinetic resolutionof the acids gives rise to esters V - VII enriched in R-diastereoisomer.