1137726-82-9

Basic information

• Product Name: C₅₈H₆₄N₉O₈P
• Synonyms: C₅₈H₆₄N₉O₈P
• CAS NO: 1137726-82-9
• Molecular Weight: 1046.18
• Mol File: 1137726-82-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₅₈H₆₄N₉O₈P(CAS DataBase Reference)
• NIST Chemistry Reference: C₅₈H₆₄N₉O₈P(1137726-82-9)
• EPA Substance Registry System: C₅₈H₆₄N₉O₈P(1137726-82-9)

Safety Data

• Hazardous Substances Data: 1137726-82-9(Hazardous Substances Data)

Upstream product

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• 1009639-13-7 8-[acetyl(9H-fluoren-2-yl)amino]-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine 
• 51549-35-0 3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine 
• 53-95-2 N-Hydroxy-2-acetylaminofluoren 
• 961-07-9 2'-Deoxyguanosine 
• 53-94-1 N-(9H-fluoren-2-yl)hydroxylamine 
• 607-57-8 2-nitro-9H-fluorene 

Relevant articles and documents

Synthesis of site-specific damaged DNA strands by 8-(acetylarylamino)- 2′-deoxyguanosine adducts and effects on various DNA polymerases

Beside the predominately found 8-(arylamino)-2′-dG, 8-(acetylarylamino) damages within DNA-strands may also play an important role in the induction of chemical carcinogenesis. A synthesis pathway leading to these 8-(acetylarylamino)-dG adducts using different aromatic amines has been optimized. The 8-modified dGs were converted into the corresponding phosphoramidites and site-specifically incorporated into different oligonucleotides leading to DNA strands. Lesion-bearing hybrids of these damaged DNA-strands with complementary oligonucleotides were used to study their melting properties and their circular dichroism spectra. It was shown that no EcoRI restriction took place with the damage inside the cleavage site. Finally, three different DNA polymerases were used for primer extension studies. C8-NAc-Arylamine adducts of 2′-deoxyguanosine with various aromatic amines were synthesized by using cross-coupling reactions and converted into 3′-phosphoramidites. Site-specific damaged NarI-, EcoRI- and 20mer-oligonucleotides were prepared by automated DNA-synthesis. Biophysical properties, restriction endonuclease studies and DNA-polymerase assays were performed. Copyright