1137837-92-3

Basic information

• Product Name: tert-butyl (E)-3-(3',4'-dimethoxyphenyl)prop-2-en-1-yl carbonate
• CAS NO: 1137837-92-3
• Molecular Weight: 294.348
• Mol File: 1137837-92-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl (E)-3-(3',4'-dimethoxyphenyl)prop-2-en-1-yl carbonate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (E)-3-(3',4'-dimethoxyphenyl)prop-2-en-1-yl carbonate(1137837-92-3)
• EPA Substance Registry System: tert-butyl (E)-3-(3',4'-dimethoxyphenyl)prop-2-en-1-yl carbonate(1137837-92-3)

Safety Data

• Hazardous Substances Data: 1137837-92-3(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 40918-90-9 3'-Hydroxymethyleugenol 

Relevant articles and documents

Preparation of Boc-protected cinnamyl-type alcohols: A comparison of the Suzuki-Miyaura coupling, cross-metathesis, and Horner-Wadsworth-Emmons approaches and their merit in parallel synthesis

Three synthetic strategies for the construction of tert-butyl (E)-3-arylprop-2-en-1-ol carbonates are described. Complementary approaches employing Suzuki-Miyaura coupling and cross-metathesis reaction gave moderate yields of the title compounds in one-step, both methods are suitable for high-throughput and parallel chemistry. A detailed investigation into the Suzuki-Miyaura coupling reaction is provided along with the studies on the synthesis of pinacolyl 1-(tert-butyloxycarbonyl)propenol-3-ylboronate, the key building block. Conventional synthesis of the title compounds via the Horner-Wadsworth-Emmons reaction as a key step in a three-step-one-purification protocol was optimized and the results are compared with those of the latter reactions.