1138122-27-6Relevant articles and documents
Insights into the mechanism of the antibiotic-synthesizing enzyme MoeO5 from crystal structures of different complexes
Ren, Feifei,Ko, Tzu-Ping,Feng, Xinxin,Huang, Chun-Hsiang,Chan, Hsiu-Chien,Hu, Yumei,Wang, Ke,Ma, Yanhe,Liang, Po-Huang,Wang, Andrew H.-J.,Oldfield, Eric,Guo, Rey-Ting
, p. 4157 - 4160 (2012)
Barrel-shaped: The enzyme MoeO5 catalyzes the transfer of the C 15 moiety of farnesyl pyrophosphate to the 2-hydroxy group of 3-phosphoglycerate to give 2-(Z,E)-farnesyl-3-phosphoglycerate (FPG; ligand in the center of the shown structure). X-ray crystallographic structures showed that MoeO5 forms a triose-phosphate-isomerase barrel structure and binds FPG in a curved pocket, mainly as a result of its long λ3 loop (magenta in picture). Copyright
