1138239-43-6

Basic information

• Product Name: 4-[4-(toluene-4-sulfonylamino)-phenyl]-butyric acid ethyl ester
• Synonyms: 4-[4-(toluene-4-sulfonylamino)-phenyl]-butyric acid ethyl ester
• CAS NO: 1138239-43-6
• Molecular Weight: 361.462
• Mol File: 1138239-43-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-[4-(toluene-4-sulfonylamino)-phenyl]-butyric acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(toluene-4-sulfonylamino)-phenyl]-butyric acid ethyl ester(1138239-43-6)
• EPA Substance Registry System: 4-[4-(toluene-4-sulfonylamino)-phenyl]-butyric acid ethyl ester(1138239-43-6)

Safety Data

• Hazardous Substances Data: 1138239-43-6(Hazardous Substances Data)

Upstream product

• 2969-81-5 Ethyl 4-bromobutyrate 
• 32857-48-0 N-(4-bromophenyl)-4-methylbenzenesulfonamide 
• 158268-30-5 N-tosyl-4-iodoaniline 

Relevant articles and documents

Nickel-catalyzed cross-coupling of aryl halides with alkyl halides: Ethyl 4-(4-(4-methylphenylsulfonamido)-phenyl)butanoate

-

Negishi cross-couplings compatible with unprotected amide functions

The reaction conditions that allow a general Pd-catalyzed Negishi cross-coupling of a functionalized alkyl, aryl, heteroaryl, and benzylic zinc reagents with aryl acidic hydrogens were investigated. A dry and argon flushed 10 mL Schlenk-tube was charged with N-benzyl-4-bromobenzamide, Pd(OAc) 2, S-PHOS, and THF. 3-pentanoyl-benzylzinc chloride was added slowly over 90 minutes with a syringe pump. The reaction mixture was stirred for 1 hour at 25 °C. The reaction mixture was quenched with a saturated NH 4Cl solution and extracted with diethyl ether. The combined phases were then washed with a aqueous thiourea solution and dried over Na 2SO4. It was observed that the mild conditions considerably increase the ability of the Negishi cross-coupling in the synthesis of complex molecules and natural products.