113853-62-6Relevant articles and documents
Chemical decontamination of iPS cell-derived neural cell mixtures
Mao, Di,Chung, Xie Khim Watson,Andoh-Noda, Tomoko,Qin, Ying,Sato, Shin-Ichi,Takemoto, Yasushi,Akamatsu, Wado,Okano, Hideyuki,Uesugi, Motonari
supporting information, p. 1355 - 1358 (2018/02/14)
This report describes the design and evaluation of phosphorylated 7-ethyl-10-hydroxycamptothecin (SN38-P), which selectively eliminates tumor-forming proliferative stem cells, including human induced pluripotent stem cells (hiPSCs) and neural stem cells, from iPSC-derived neural cell mixtures. Results of the present study demonstrate that simple phosphorylation of an anticancer drug can provide a safe, cost-effective, and chemically-defined tool for decontaminating hiPSC-derived neuron.