1138566-90-1

Basic information

• Product Name: [1-(4-trifluoromethoxyphenyl)-methylidene]-hydrazine
• Synonyms: [1-(4-trifluoromethoxyphenyl)-methylidene]-hydrazine
• CAS NO: 1138566-90-1
• Molecular Weight: 204.152
• Mol File: 1138566-90-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: [1-(4-trifluoromethoxyphenyl)-methylidene]-hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: [1-(4-trifluoromethoxyphenyl)-methylidene]-hydrazine(1138566-90-1)
• EPA Substance Registry System: [1-(4-trifluoromethoxyphenyl)-methylidene]-hydrazine(1138566-90-1)

Safety Data

• Hazardous Substances Data: 1138566-90-1(Hazardous Substances Data)

Upstream product

• 659-28-9 p-trifluoromethoxybenzaldehyde 

Downstream Products

• 1138566-66-1 (4-Chloro-6-{N'-[1-(4-trifluoromethoxyphenyl)-methylidene]-hydrazino}-[1,3,5]triazin-2-yl)-(4-fluoro-3-trifluoromethylphenyl)-amine 
• 1356484-21-3 4-(2-chloro-6-fluorophenyl)-N-(4-chlorophenyl)-6-(2-(4-(trifluoromethoxy)benzylidene)hydrazinyl)-1,3,5-triazine-2-amine 
• 4315-07-5 4-(trifluoromethoxy)phenylacetic acid 

Relevant articles and documents

Palladium-Catalyzed Defluorinative Alkylation of gem-Difluorocyclopropanes: Switching Regioselectivity via Simple Hydrazones

Conventional approaches for Pd-catalyzed ring-opening cross-couplings of gem-difluorocyclopropanes with nucleophiles predominantly deliver the β-fluoroalkene scaffolds (linear selectivity). Herein, we report a cooperative strategy that can completely switch the reaction selectivity to give the alkylated α-fluoroalkene skeletons (branched selectivity). The unique reactivity of hydrazones that enables analogous inner-sphere 3,3′-reductive elimination driven by denitrogenation, as well as the assistance of steric-embedded N-heterocyclic carbene ligand, are the key to switch the regioselectivity. A wide range of hydrazones derived from naturally abundant aryl and alkyl aldehydes are well applicable, and various gem-difluorocyclopropanes, including modified pharmaceutical and biological molecules, can be efficiently functionalized with high value alkylated α-fluorinated alkene motifs under mild conditions.

Palladium-Catalyzed Formal Hydroalkylation of Aryl-Substituted Alkynes with Hydrazones

We have developed an unprecedented Pd-catalyzed formal hydroalkylation of alkynes with hydrazones, which are generated in situ from naturally abundant aldehydes, as both alkylation reagents and hydrogen donors. The hydroalkylation proceeds with high regio- and stereoselectivity to form (Z)-alkenes, which are more difficult to generate compared to (E)-alkenes. The reaction is compatible with a wide range of functional groups, including hydroxy, ester, ketone, nitrile, boronic ester, amine, and halide groups. Furthermore, late-stage modifications of natural products and pharmaceutical derivatives exemplify its unique chemoselectivity, regioselectivity, and synthetic applicability. Mechanistic studies indicate the possible involvement of Pd-hydride intermediates.

Insecticidal Triazines and Pyrimidines

The present invention describes novel triazines, their related pyrimidines and their use in controlling insects. This invention also includes new synthetic procedures, intermediates for preparing the compounds, pesticide compositions containing the compou