113858-90-5

Basic information

• Product Name: ETHYL 5-CYANO-6-MERCAPTO-2-METHYLNICOTINATE
• Synonyms: ETHYL 5-CYANO-6-MERCAPTO-2-METHYLNICOTINATE;ETHYL 3-CYANO-2-MERCAPTO-6-METHYLPYRIDINE-5-CARBOXYLATE
• CAS NO: 113858-90-5
• Molecular Formula: C₁₀H₁₀N₂O₂S
• Molecular Weight: 222.26
• Mol File: 113858-90-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 302.8°Cat760mmHg
• Flash Point: 136.9°C
• Appearance: /
• Density: 1.29g/cm³
• Vapor Pressure: 0.000653mmHg at 25°C
• CAS DataBase Reference: ETHYL 5-CYANO-6-MERCAPTO-2-METHYLNICOTINATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 5-CYANO-6-MERCAPTO-2-METHYLNICOTINATE(113858-90-5)
• EPA Substance Registry System: ETHYL 5-CYANO-6-MERCAPTO-2-METHYLNICOTINATE(113858-90-5)

Safety Data

• Hazardous Substances Data: 113858-90-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H10N2O2S/c1-3-14-10(13)8-4-7(5-11)9(15)12-6(8)2/h4,13H,3H2,1-2H3/p-1

Upstream product

• 7357-70-2 Cyanothioacetamide 
• 141-97-9 ethyl acetoacetate 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 134653-70-6 ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate 
• 90113-28-3 ethyl 2-ethoxymethylacetoacetate 
• 64119-42-2 ethyl 6-chloro-5-cyano-2-methylnicotinate 
• 3788-94-1 2-ethoxymethylene-3-oxobutanoic acid ethyl ester 

Downstream Products

• 113859-32-8 diethyl N-pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamate 
• 113859-37-3 N-pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamic acid 

Relevant articles and documents

Synthesis and unusual reaction of piperidinium 3-cyano-5-ethoxycarbonyl-4- (1H-indol-3-yl)-6-methyl-1,4-dihydropyridine-2-thiolate with glacial acetic acid

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Polysubstituted thieno[2,3-b]pyridine derivatives, and preparation method and application thereof

The invention discloses polysubstituted thieno[2,3-b]pyridine derivatives, and a preparation method and an application thereof. The structural formula of the derivatives are represented by formula I shown in the description. A compound for inhibiting a urea transporter is screened by using an erythrocyte model. Experimental results show that the compounds (represented by formula I-1) can inhibit the permeation of a urea transporter UT-B mediated erythrocyte membrane to urea, and the effect of the compounds has a dose-dependent relationship; the compounds represented by the formula I-1 have nocytotoxic effect on MDCK cells within an effective dose range, so the effect of the compounds represented by the formula I-1 on inhibiting cell permeation urea is irrelevant to the cytotoxicity of thecompounds; the inhibition effect of the compounds represented by the formula I-1 on the urea transporter UT-B is gradually enhanced; the inhibiting effect of the compounds represented by the formulaI-1 on the UT-B is reversible; and in-vivo test results show that the compounds represented by the formula I-1 can significantly increase the urination volume of rats, reduce the concentration of ureain rat urine and reduce the osmotic pressure, so that the compounds represented by the formula I-1 generate a urea selective diuresis effect in vivo.

Synthesis of 2,3,5,6-tetrasubstituted pyridines from enamines derived from N,N-dimethylformamide dimethyl acetal

Reactions of 1,3-dicarbonyl compounds with N,N-dimethylformamide dimethyl acetal, followed by cyanothioacetamide or cyanoacetamide and sodium hydride, then acidification, give 5,6-disubstituted 3-cyanopyridine-2(1H)-thiones or 5,6-disubstituted 3-cyanopyridin-2(1H)-ones 4. Analogous reactions with the malononitrile dimer give 5,6-disubstituted 3-cyano-2-(dicyanomethylene)-1,2-dihydropyridines 9.