113886-70-7

Basic information

• Product Name: 2'-(O-METHYL)-5-METHYLCYTIDINE
• Synonyms: 2'-(O-METHYL)-5-METHYLCYTIDINE;5-METHYL-2'-O-METHYLCYTIDINE;2'-O-Methyl-5-methyl-D-cytidine;5-Me-2'-OMe-C;2'-OME-5-ME-C
• CAS NO: 113886-70-7
• Molecular Formula: C11H17N3O5
• Molecular Weight: 271.27
• Mol File: 113886-70-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 504.6±60.0 °C(Predicted)
• Appearance: /
• Density: 1.61±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Water (Slightly, Sonicated)
• PKA: 13.37±0.70(Predicted)
• CAS DataBase Reference: 2'-(O-METHYL)-5-METHYLCYTIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-(O-METHYL)-5-METHYLCYTIDINE(113886-70-7)
• EPA Substance Registry System: 2'-(O-METHYL)-5-METHYLCYTIDINE(113886-70-7)

Safety Data

• Hazardous Substances Data: 113886-70-7(Hazardous Substances Data)

Usage

Description

2'-(O-METHYL)-5-METHYLCYTIDINE is a modified nucleoside derivative that is found in tRNAs from extremely thermophilic archaebacteria. It is characterized by the presence of a methyl group at the 5' position and an O-methyl group at the 2' position of the cytidine base. This modification plays a crucial role in the stability and function of the tRNA molecule, particularly in extreme temperature conditions.

Uses

Used in Molecular Biology Research:
2'-(O-METHYL)-5-METHYLCYTIDINE is used as a key component in the study of tRNA structure and function, particularly in understanding the adaptations of archaebacteria to high-temperature environments. Its presence in tRNA molecules helps researchers investigate the mechanisms of translation and protein synthesis in these extremophiles.
Used in Drug Development:
2'-(O-METHYL)-5-METHYLCYTIDINE is used as a potential therapeutic agent for targeting specific molecular pathways in cancer cells. Its ability to destabilize triplex formation with double-stranded DNA may have implications in the development of novel anticancer drugs that can interfere with the genetic stability of cancer cells, thereby inhibiting their growth and proliferation.
Used in Biochemical Applications:
2'-(O-METHYL)-5-METHYLCYTIDINE can be employed as a biochemical tool for studying the interactions between nucleic acids and proteins, as well as for developing new methods in molecular diagnostics and gene therapy. Its unique structural features make it a valuable compound for exploring the role of modified nucleosides in various biological processes.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2'-(O-METHYL)-5-METHYLCYTIDINE is used as a starting material or intermediate in the synthesis of other bioactive compounds with potential therapeutic applications. Its unique chemical properties allow for the development of novel drug candidates that can target specific molecular pathways involved in various diseases, including cancer and other genetic disorders.
Used in Nanotechnology:
2'-(O-METHYL)-5-METHYLCYTIDINE can be utilized in the field of nanotechnology for the design and development of nanoscale drug delivery systems. Its interaction with double-stranded DNA and its stability under extreme conditions make it a promising candidate for the development of targeted drug delivery systems that can improve the efficacy and bioavailability of therapeutic agents.