113932-23-3

Basic information

• Product Name: 2-chlorocarbonyl-2-phenyl-acetic acid ethyl ester
• CAS NO: 113932-23-3
• Molecular Weight: 226.66
• Mol File: 113932-23-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-chlorocarbonyl-2-phenyl-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chlorocarbonyl-2-phenyl-acetic acid ethyl ester(113932-23-3)
• EPA Substance Registry System: 2-chlorocarbonyl-2-phenyl-acetic acid ethyl ester(113932-23-3)

Safety Data

• Hazardous Substances Data: 113932-23-3(Hazardous Substances Data)

Upstream product

• 83-13-6 diethyl 2-phenylmalonate 

Downstream Products

• 1228457-80-4 ethyl (E)-5-methyl-3,4-dioxo-2,6-diphenylhex-5-enoate 
• 1392325-33-5 ethyl (E)-5-methyl-3,4-dioxo-2-phenylhept-5-enoate 
• 1392325-24-4 C₂₃H₃₃NO₄Si 
• 36277-53-9 C₁₁H₁₀O₃ 
• 41951-10-4 2,N-diphenyl-malonamic acid 
• 259248-79-8 N,N-dimethyl-α-phenylmalonamic acid 
• 7713-73-7 N-methyl-α-phenylmalonamic acid 
• 51431-13-1 phenylmalonamic acid 
• 61082-01-7 N-tert-butyl-α-phenylmalonamic acid 
• 177543-39-4 ethyl 3-(3-morpholino-1H-inden-2-yl)-3-oxo-2-phenylpropionate 
• 7713-74-8 ethyl 3-(methylamino)-3-oxo-2-phenylpropanoate 
• 20628-57-3 ethyl 2-(phenylcarbamoyl)-2-phenylacetate 

Relevant articles and documents

Hydrogen-Bonding Assisted Catalytic Kinetic Resolution of Acyclic β-Hydroxy Amides

Enantioenriched acyclic α-substituted β-hydroxy amides are valuable compounds in chemical, material and medicinal sciences, but their enantioselective synthesis remains challenging. A catalytic kinetic resolution (KR) of such amides with selectivity factor(s) up to >200 is developed via enantioselective acylation of primary alcohol with N-heterocyclic carbene. An enhanced selectivity for the catalytic KR process is realized using cyclic tertiary amine as base additive. Diastereomeric transition state models for the process are proposed to rationalize the origin of enantioselectivity.

Neutral nazarov-type cyclization catalyzed by palladium(0)

Joining the circle: The first Pd0 catalyzed Nazarov-type cyclization of diketoesters (see scheme) proceeds in 70 % to 95 % yield under strictly neutral pH conditions. Aryl substitution of the diketoesters is not required, so the reaction shows great versatility and can also proceed with aliphatic substrates. Copyright