113984-67-1

Basic information

• Product Name: Benzaldehyde, 5-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-2-fluoro-
• Synonyms: Benzaldehyde, 5-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-2-fluoro-;5-[(tert-butyldiMethylsilyl)oxy]-2- fluorobenzaldehyde
• CAS NO: 113984-67-1
• Molecular Formula: C₁₃H₁₉FO₂Si
• Molecular Weight: 254.3726632
• Mol File: 113984-67-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 292.0±25.0 °C(Predicted)
• Appearance: /
• Density: 1.027±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzaldehyde, 5-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-2-fluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 5-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-2-fluoro-(113984-67-1)
• EPA Substance Registry System: Benzaldehyde, 5-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-2-fluoro-(113984-67-1)

Safety Data

• Hazardous Substances Data: 113984-67-1(Hazardous Substances Data)

Usage

General Description

Benzaldehyde, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-fluoro- is a chemical compound that is a derivative of benzaldehyde. It contains a fluoro group at the 2-position and a t-butyl dimethylsilyl ether at the 5-position. Benzaldehyde, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-fluoro- is commonly used as a building block in organic synthesis, particularly in the preparation of pharmaceuticals and agrochemicals. Its unique structure and reactivity make it a valuable intermediate in the production of various drugs and chemical products. Additionally, this compound has potential applications in medicinal chemistry and drug discovery due to its favorable chemical properties.

Upstream product

• 371-41-5 4-Fluorophenol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 113984-68-2 4-<(dimethyl-tert-butylsilyl)oxy>fluorobenzene 
• 103438-84-2 methyl 2-amino-3-(2-fluoro-5-hydroxyphenyl)propanoate 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 105728-90-3 2-fluoro-5-methoxybenzaldehyde 
• 103438-92-2 5-benzyloxy-2-fluorobenzaldehyde 
• 103438-84-2 methyl 2-amino-3-(2-fluoro-5-hydroxyphenyl)propanoate 

Relevant articles and documents

COMPOUNDS AND COMPOSITIONS FOR USE IN TREATING SKIN DISORDERS

Provided herein is a compound of formula (XXXII) or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer thereof or a physiologically functional derivative thereof, wherein R1, R2, R3, G, A, E, n, p, and q are defined herein. Also provided herein are compositions comprising a compound of formula (XXXII), and methods of using a compound of formula (XXXII), e.g., in the treatment or prevention of skin disorders.

SUBSTITUTED DIHYDROPYRIDINES AND METHODS OF USE

Compounds are provided that are modulators of the C5a receptor. The compounds are substituted dihydropyridines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of C5a receptors.

Unexpected Regioselectivity in the Lithiation of Fluoroanisoles

The regioselectivity of lithiation of a series of fluoroanisoles and fluoroveratroles has been studied by determining the ratio of isomeric aldehydes produced by dimethylformamide quenching.The position of lithiation is influenced by such factors as temperature and time of the reaction.Contrary to published reports, fluorine competes significantly with the methoxy group as an ortho director in lithiation reactions.Lithiation of dimethyl-tert-butylsilyl ethers of fluorophenols proceeds exclusively ortho to fluorine.