113986-29-1Relevant articles and documents
A simple and fast procedure for efficient synthesis of β- and γ-azidoarylketones
Singh, Pradeep N. D.,Muthukrishnan, Sivaramakrishnan,Murthy, Rajesh S.,Klima, Rodney F.,Mandel, Sarah M.,Hawk, Michael,Yarbrough, Nina,Gudmundsdottir, Anna D.
, p. 9169 - 9172 (2003)
A simple and efficient method for preparing β- and γ-azido substituted arylketones has been achieved by short microwave irradiation of the corresponding halo arylketones and sodium azide in DMSO.
Regiocontrolled Wacker Oxidation of Cinnamyl Azides
Carlson, Angela S.,Calcanas, Cristian,Brunner, Ryan M.,Topczewski, Joseph J.
supporting information, p. 1604 - 1607 (2018/03/23)
A highly regioselective Wacker oxidation has been developed for the oxidation of cinnamyl azides. The catalytic oxidation tolerates the azide functionality, and more than 15 β-azido ketones were isolated (25-92% yield). High regioselectivity for the aryl ketone is observed in all cases. A robustness screen was conducted to determine functional group tolerance. The products of the oxidaiton can be readily diversified.
Azido carbonyl compounds as DNA cleaving agents
Chowdhury, Nilanjana,Dutta, Sansa,Karthick,Anoop, Anakuthil,Dasgupta, Swagata,Pradeep Singh
, p. 25 - 34 (2012/11/07)
Irradiation of azido carbonyl compounds using UV light (≥310 nm) produced triplet alkyl nitrenes and aroyl radicals, which resulted in efficient cleavage of single strand DNA at pH 7.0. DNA cleaving ability of azido carbonyl compounds was found to be dependent on its concentration and substituents on its aromatic ring. Further, newly synthesized naphthalene based azido carbonyl compounds showed DNA cleavage ability at longer wavelength of UV light (≥350 nm) and also binding studies revealed that they bind to ct-DNA by weak intercalation mode.
