1139906-49-2

Basic information

• Product Name: C₈₆H₉₂N₂O₁₆
• Synonyms: C₈₆H₉₂N₂O₁₆
• CAS NO: 1139906-49-2
• Molecular Weight: 1409.68
• Mol File: 1139906-49-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₈₆H₉₂N₂O₁₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₈₆H₉₂N₂O₁₆(1139906-49-2)
• EPA Substance Registry System: C₈₆H₉₂N₂O₁₆(1139906-49-2)

Safety Data

• Hazardous Substances Data: 1139906-49-2(Hazardous Substances Data)

Upstream product

• 859838-48-5 aminoethyl 2,3,6-tri-O-benzyl-4-O-(2,3,4,6-tetra-O-benzyl-β-D-galactopyranosyl)-β-D-glucopyranoside 
• 129460-09-9 Fmoc-Asp-O-t-Bu 

Downstream Products

• 1139906-51-6 C₈₂H₈₄N₂O₁₆ 

Relevant articles and documents

Synthesis and antibacterial activities of novel tyrocidine A glycosylated derivatives towards multidrug-resistant pathogens

Glycosylation can have a multifaceted impact on the properties and functions of peptides and plays a critical role in interacting with or binding to the target molecules. Herein, based on the previously reported method for macrocyclic glycopeptide synthesis, two series of tyrocidine A glycosylated derivatives (1a-f and 2a-f) were synthesized and evaluated for their antibacterial activities to further study the structure and activity relationships (SAR). Biological studies showed that the synthetic glycosylated derivatives had good antibacterial activities towards methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus. SAR studies based on various glycans and linkages were used to enhance the biochemical profile, resulting in the identification of several potent antibiotics, such as 1f, with a great improved therapeutic index than tyrocidine A.