1139921-57-5Relevant articles and documents
Catalytic Selective Metal-Free Cross-Coupling of Heteroaromatic N-Oxides with Organosilanes
Puthanveedu, Mahesh,Polychronidou, Vasiliki,Antonchick, Andrey P.
, p. 3407 - 3411 (2019)
A metal-free, regioselective C-H functionalization of heteroaromatic N-oxides has been developed. The method enables the synthesis of various benzylated and alkynylated N-heterocycles in a transition-metal-free manner employing organosilanes as coupling partners. The unanticipated reactivity has been exploited for the synthesis of a number of symmetrical disubstituted acetylenes from ethynyltrimethylsilane via carbon-silicon bond metathesis.
Synthesis of 2-Substituted Quinolines via Rhodium(III)-Catalyzed C–H Activation of Imidamides and Coupling with Cyclopropanols
Zhou, Xukai,Qi, Zisong,Yu, Songjie,Kong, Lingheng,Li, Yang,Tian, Wan-Fa,Li, Xingwei
, p. 1620 - 1625 (2017/05/22)
An efficient synthesis of 2-substituted quinolines from readily available cyclopropanols and imidamides has been developed, where the cyclopropanol acts as a C3 synthon. With the assistance of a bifunctional imidamide directing group, the reaction occurred via sequential C–H/C–C cleavage and C–C/C–N bond formation. (Figure presented.).
Highly enantioselective iridium-Catalyzed hydrogenation of 2-Benzylquinolines and 2-Functionalized and 2,3-disubstituted quinolines
Wang, Da-Wei,Wang, Xiao-Bing,Wang, Duo-Sheng,Lu, Sheng-Mei,Zhou, Yong-Gui,Li, Yu-Xue
supporting information; experimental part, p. 2780 - 2787 (2009/08/08)
The enantioselective hydrogenation of 2-benzylquinolines and 2-functionalized and 2,3-disubstituted quinohnes was developed by using the [Ir(COD)Cl]2/bisphosphine/I2 system with up to 96% ee. Moreover, mechanistic studies revealed the hydrogenation mechanism of quinoline involves a 1,4-hydride addition, isomerization, and 1,2-hydride addition, and the catalytic active species may be a Ir(III) complex with chloride and iodide.
