114031-67-3

Basic information

• Product Name: 4-HYDROXY-4'-(TRIMETHYLACETOXY)BENZOPHENONE
• Synonyms: 4-HYDROXY-4'-(TRIMETHYLACETOXY)BENZOPHENONE;2,2-DiMethyl-propanoic Acid 4-(4-Hydroxybenzoyl)phenyl Ester
• CAS NO: 114031-67-3
• Molecular Formula: C₁₈H₁₈O₄
• Molecular Weight: 298.33
• Product Categories: Aromatics
• Mol File: 114031-67-3.mol
• Article Data: 16

Chemical Properties

• Melting Point: 182-184°C
• Boiling Point: 458.8±30.0 °C(Predicted)
• Appearance: /
• Density: 1.178±0.06 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility: Dichloromethane, Ethyl Acetate, Methanol
• PKA: 7.75±0.15(Predicted)
• CAS DataBase Reference: 4-HYDROXY-4'-(TRIMETHYLACETOXY)BENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-4'-(TRIMETHYLACETOXY)BENZOPHENONE(114031-67-3)
• EPA Substance Registry System: 4-HYDROXY-4'-(TRIMETHYLACETOXY)BENZOPHENONE(114031-67-3)

Safety Data

• Hazardous Substances Data: 114031-67-3(Hazardous Substances Data)

Usage

Description

4-HYDROXY-4'-(TRIMETHYLACETOXY)BENZOPHENONE, also known as 4-Hydroxy-4'-(trimethylacetoxy)benzophenone (CAS# 114031-67-3), is an organic compound that plays a significant role in various chemical reactions and processes. It is characterized by its molecular structure, which features a hydroxyl group and a trimethylacetoxy group attached to a benzophenone backbone. This unique structure endows it with specific properties that make it valuable in a range of applications.

Uses

Used in Organic Synthesis:
4-HYDROXY-4'-(TRIMETHYLACETOXY)BENZOPHENONE is used as an intermediate in the synthesis of various organic compounds. Its unique structure allows it to participate in a wide range of chemical reactions, making it a versatile building block for the creation of new molecules with diverse properties and applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-HYDROXY-4'-(TRIMETHYLACETOXY)BENZOPHENONE is used as a key component in the development of new drugs. Its ability to undergo various chemical transformations enables the creation of novel drug candidates with potential therapeutic benefits.
Used in Chemical Research:
4-HYDROXY-4'-(TRIMETHYLACETOXY)BENZOPHENONE is also utilized in chemical research as a model compound for studying reaction mechanisms and exploring new synthetic pathways. Its reactivity and structural features make it an ideal candidate for investigating various aspects of organic chemistry, including reaction kinetics, stereochemistry, and catalysis.
Used in Material Science:
In the field of material science, 4-HYDROXY-4'-(TRIMETHYLACETOXY)BENZOPHENONE can be employed in the development of new materials with specific properties. Its incorporation into polymers, for example, can lead to materials with enhanced thermal stability, mechanical strength, or optical properties, depending on the desired application.

Upstream product

• 611-99-4 4,4'-Dihydroxybenzophenone 
• 112004-83-8 [4-[4-(2,2-dimethylpropanoyloxy)benzoyl]phenyl] 2,2-dimethylpropanoate 
• 3282-30-2 pivaloyl chloride 
• 7065-46-5 3,3-dimethylbutanoic acid chloride 

Downstream Products

• 1440533-08-3 (Z)-4-(1-(4-(2-amino-2-oxoethoxy)phenyl)-2-phenylbut-1-enyl)phenyl Pivalate 
• 1308808-22-1 (Z)-4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-enyl)phenol 
• 1440533-06-1 (E)-4-(1-(4-(2-amino-2-oxoethoxy)phenyl)-2-phenylbut-1-enyl)phenyl Pivalate 
• 1394929-55-5 (E)-4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-enyl)phenol 
• 877387-37-6 (Z)-5-[4-(2-dimethylamino-ethoxy)-phenyl]-5-(4-hydroxyphenyl)-4-phenyl-pent-4-ene-1-ol 

Relevant articles and documents

Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRγ

The design and synthesis of 4-hydroxytamoxifen (4-OHT) derivatives are described. The binding affinities of these compounds toward the orphan estrogen-related receptor γ and the classical estrogen receptor α demonstrate that analogs bearing hydroxyalkyl g

Rational design of ERα targeting hypoxia turn-on fluorescent probes with antiproliferative activity for breast cancer

The overexpression of estrogen receptor (ER) α is not only closely related to the development of ER+ breast cancer, but is also an important biomarker for clinical diagnosis and treatment. Herein, we report several ERα targeting hypoxia turn-on fluorescent probes with antitumor activity for breast cancer cells. Among them, probes 3 and 5 displayed good ERα targeting ability and favorable hypoxia turn-on response in MCF-7 cells. Moreover, the probes 3 and 5 exhibited good antiproliferative activity towards MCF-7 cells (IC50 = 8.5 μM, 10.3 μM) and a much lower cytotoxicity to normal cells compared with the positive control. It is expected that these novel fluorescent probes may provide useful tools for the theranostics of ER+ breast cancer.

NOVEL ARYL ETHANE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT

The present invention relates to an aryl ethene derivative, for inhibiting an estrogen-related receptor gamma (ERRγ) activity, a prodrug of same, a solvate of same, a stereoisomer of same or pharmaceutically acceptable salts of same, and a pharmaceutical

NOVEL ARYL ETHENE DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT

The present invention relates to an aryl ethene derivative represented by chemical formula 1 which suppresses the activity of estrogen-related receptor gamma (ERRandgamma;), a prodrug thereof, a solvate thereof, a stereomer thereof, or a pharmaceutically acceptable salt thereof, and to a pharmaceutical composition comprising the same as an effective component. In the chemical formula 1, R^1, R^2, L and Ar are the same as defined in the detailed description of the invention.COPYRIGHT KIPO 2018