1140627-78-6

Basic information

• Product Name: 1-(4-methoxyphenyl)-N-methylimidazo[1,2-a]quinoxalin-4-amine
• Synonyms: 1-(4-methoxyphenyl)-N-methylimidazo[1,2-a]quinoxalin-4-amine
• CAS NO: 1140627-78-6
• Molecular Weight: 304.351
• Mol File: 1140627-78-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(4-methoxyphenyl)-N-methylimidazo[1,2-a]quinoxalin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxyphenyl)-N-methylimidazo[1,2-a]quinoxalin-4-amine(1140627-78-6)
• EPA Substance Registry System: 1-(4-methoxyphenyl)-N-methylimidazo[1,2-a]quinoxalin-4-amine(1140627-78-6)

Safety Data

• Hazardous Substances Data: 1140627-78-6(Hazardous Substances Data)

Upstream product

• 1140627-75-3 1-bromo-N-methylimidazo[1,2-a]-quinoxalin-4-amine 
• 5720-07-0 4-methoxyphenylboronic acid 
• 191349-69-6 4-chloroimidazo[1,2-a]quinoxaline 
• 56361-94-5 PMP acetal 

Relevant articles and documents

New imidazoquinoxaline derivatives: Synthesis, biological evaluation on melanoma, effect on tubulin polymerization and structure-activity relationships

Microtubules are considered as important targets of anticancer therapy. EAPB0503 and its structural imidazo[1,2-a]quinoxaline derivatives are major microtubule-interfering agents with potent anticancer activity. In this study, the synthesis of several new derivatives of EAPB0503 is described, and the anticancer efficacy of 13 novel derivatives on A375 human melanoma cell line is reported. All new compounds show significant antiproliferative activity with IC50 in the range of 0.077-122 μM against human melanoma cell line (A375). Direct inhibition of tubulin polymerization assay in vitro is also assessed. Results show that compounds 6b, 6e, 6g, and EAPB0503 highly inhibit tubulin polymerization with percentages of inhibition of 99%, 98%, 90%, and 84% respectively. Structure-activity relationship studies within the series are also discussed in line with molecular docking studies into the colchicine-binding site of tubulin.

New imidazo[1,2-a]quinoxaline derivatives: Synthesis and in vitro activity against human melanoma

New imidazo[1,2-a]quinoxaline analogues have been synthesized in good yields via a bimolecular condensation of 2-imidazole carboxylic acid, followed by a coupling with ortho-fluoroaniline and subsequent substitution on the imidazole ring by Suzuki Cross-c