1142816-82-7

Basic information

• Product Name: C₈H₈NOS₂^(1-)*K⁽¹⁺⁾
• Synonyms: C₈H₈NOS₂^(1-)*K⁽¹⁺⁾
• CAS NO: 1142816-82-7
• Molecular Weight: 237.388
• Mol File: 1142816-82-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: C₈H₈NOS₂^(1-)*K⁽¹⁺⁾(CAS DataBase Reference)
• NIST Chemistry Reference: C₈H₈NOS₂^(1-)*K⁽¹⁺⁾(1142816-82-7)
• EPA Substance Registry System: C₈H₈NOS₂^(1-)*K⁽¹⁺⁾(1142816-82-7)

Safety Data

• Hazardous Substances Data: 1142816-82-7(Hazardous Substances Data)

Upstream product

• 75-15-0 carbon disulfide 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 40207-03-2 p-Anisidinothioformyl-hydrazin 
• 2284-20-0 4-Methoxyphenyl isothiocyanate 
• 7382-39-0 1-(p-methoxyphenyl)-3-thiosemicarbazide 

Relevant articles and documents

An efficient one-pot strategy for the synthesis of 4- methylene-2-thiazolidinethiones in water

A simple and efficient, one-pot strategy for the preparation of 4-methylene-2-thiazolidinethiones has been developed. This protocol involved condensation of primary amines with carbon disulfide in water to generate the dithiocarbamate salts in situ, which coupled with 2,3-dibromopropene, followed by intramolecular cyclization to the corresponding heterocycles in moderate to good yields.

Enantioselective synthesis of 3,5-disubstituted thiohydantoins and hydantoins

A mild method to convert optically pure amino acid thiourea and urea derivatives to thiohydantoins and hydantoins, respectively, is described. It provides an efficient way to realize enantioselective synthesis of thiohydantoins and hydantoins with good to high isolated yields and enantiomeric purities. We found that the enantiomeric purities were highly dependent on the reaction conditions including bases, solvents, and temperature.

5-Nitrofuran-2-yl derivatives: Synthesis and inhibitory activities against growing and dormant mycobacterium species

Eighteen 5-nitrofuran-2-yl derivatives were prepared by reacting 5-nitro-2-furfural with various (sub)phenyl/pyridyl thiosemicarbazide using microwave irradiation. The compounds were tested for their in vitro activity against tubercular and various non-tubercular mycobacterium species in log-phase and 6-week-starved cultures. Compound N-(3,5-dibromopyridin-2-yl)-2-((5-nitrofuran-2-yl)methylene)hydrazinecarbothioamide (4r) was found to be the most potent compound (MIC: 0.22 μM) and was 3 times more active than standard isoniazid (INH) and equally active as rifampicin (RIF) in log-phase culture of Mycobacterium tuberculosis H37Rv. In starved M. tuberculosis H37Rv, 4r inhibited with MIC of 13.9 μM and was found to be 50 times more active than INH and slightly more active than RIF.