114289-28-0

Basic information

• Product Name: 4-(4-methylphenyl)thio-1,8-naphthalic anhydride
• Synonyms: 4-(4-methylphenyl)thio-1,8-naphthalic anhydride
• CAS NO: 114289-28-0
• Molecular Weight: 320.368
• Mol File: 114289-28-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-methylphenyl)thio-1,8-naphthalic anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-methylphenyl)thio-1,8-naphthalic anhydride(114289-28-0)
• EPA Substance Registry System: 4-(4-methylphenyl)thio-1,8-naphthalic anhydride(114289-28-0)

Safety Data

• Hazardous Substances Data: 114289-28-0(Hazardous Substances Data)

Upstream product

• 81-86-7 4-bromo-1,8-naphthalenedicarboxylic anhydride 
• 106-45-6 para-thiocresol 

Relevant articles and documents

Thio/oxo-naphthalimide compound and application thereof

The invention provides a thio/oxo-naphthalimide compound and application thereof. The compound has a structure shown as a general formula I. The compounds are capable of realizing competitive binding and antagonism of Bcl-2 and Mcl-1 proteins in vitro and in cells so as to induce cell apoptosis, and refer to a type of apoptosis inducers and antitumor compounds with extremely high activities. In addition, the derivative designed based on the compound can serve as a bifunctional molecule and is capable of recognizing, separating, enriching and realizing fluorescence detection of Bcl-2 family proteins; or the derivative can serve as a PROTAC bifunctional complex for selectively degrading the Bcl-2 and Mcl-1 proteins in the cells, so that the level of the Bcl-2 family proteins in living cells is regulated. The structural formula is as shown in the specification.