114326-10-2Relevant articles and documents
PROCESS FOR THE PREPARATION OF A SULFUR-AMINE
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, (2018/05/03)
The present invention relates to a process for the synthesis of cysteamine or a salt thereof.
Synthesis and evaluation of chloromethyl sulfoxides as a new class of selective irreversible cysteine protease inhibitors
Brouwer, Arwin J.,Bunschoten, Anton,Liskamp, Rob M.J.
, p. 6985 - 6993 (2008/03/28)
The synthesis and biological evaluation of a new class of selective irreversible cysteine protease inhibitors is described. A set of amino acid based chloromethyl sulfoxides was prepared and they were found to inhibit irreversibly the cysteine protease papain. They were selective for cysteine proteases since no inhibition was found for the serine protease chymotrypsin.
Synthesis of Azocine Derivatives from Thioaldehyde Diels-Alder Adducts
Vedejs, E.,Stults, J. S.
, p. 2226 - 2232 (2007/10/02)
Nitrogen-containing phenacyl sulfides 1 or 2 can be readily cleaved to thioaldehydes that are trapped by electron-rich dienes to give the adducts 4, 5, 11, or 17.The adducts have electrophilic character α to sulfur and can be converted into structures having new C-N bonds at the α-carbon.Thus, 4 leads to lactam 6 by S to N acyl transfer.A similar reaction occurs from 15 to the eight-membered 16.Internal addition of amine nitrogen to Danishefsky diene adducts 11, 17, or 26 affords bicyclic aminals which are converted into azocine derivatives upon desulfurization.Stable structures such as 24, 25, and 31 are prepared in this way.The unusual enaminone 20 is not stable and rearranges upon attempted purification to 21.
