1143579-07-0

Basic information

• Product Name: C₁₆H₂₂N₂O
• CAS NO: 1143579-07-0
• Molecular Weight: 258.363
• Mol File: 1143579-07-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₂₂N₂O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₂₂N₂O(1143579-07-0)
• EPA Substance Registry System: C₁₆H₂₂N₂O(1143579-07-0)

Safety Data

• Hazardous Substances Data: 1143579-07-0(Hazardous Substances Data)

Upstream product

• 107-10-8 propylamine 
• 620593-93-3 4-hydroxy-2-(2-hydroxyethyl)-2-(3-methoxyphenyl)butanenitrile 

Relevant articles and documents

Novel 1,4-diarylpiperidine-4-methylureas as anti-hyperlipidemic agents: Dual effectors on acyl-CoA:cholesterol O-acyltransferase and low-density lipoprotein receptor expression

A family of 1,4-diarylpiperidine-4-methylureas were designed and synthesized as novel dual effectors on ACAT and LDL receptor expression. We examined SAR of the synthesized compounds focusing on substitution at the three aromatic parts of the starting compound 1 and succeeded in identifying essential substituents for inhibition of ACAT and up-regulation of hepatic LDL receptor expression. Especially, we found that compound 12f, which can easily be prepared, has biological properties comparable to those of SMP-797, a promising ACAT inhibitor. In addition, the in vitro effects of 12f on lipid metabolism were substantially superior to those of a known ACAT inhibitor, Avasimibe.